Publications by authors named "Ferrari V"

Rhinoplasty is one of the major surgical procedures most popular and it is generally performed modelling the internal bones and cartilage using a closed approach to reduce the damage of soft tissue, whose final shape is determined by means of their new settlement over the internal remodelled rigid structures. An optimal planning, achievable thanks to advanced acquisition of 3D images and thanks to the virtual simulation of the intervention via specific software. Anyway, the final result depends also on factors that cannot be totally predicted regarding the settlement of soft tissues on the rigid structures, and a final objective check would be useful to eventually perform some adjustments before to conclude the intervention.

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Background: Hypertrophic cardiomyopathy (HCM) is a leading cause of sudden cardiac death. Current diagnosis emphasizes the detection of left ventricular hypertrophy (LVH) using a fixed threshold of ≥15-mm maximum wall thickness (MWT). This study proposes a method that considers individual demographics to adjust LVH thresholds as an alternative to a 1-size-fits-all approach.

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EGFR status assessment is mandatory for adjuvant decision-making of resected stage IB-IIIA non-squamous non-small cell lung cancer (NS-NSCLC). It is questionable whether single-gene RT-PCR versus next-generation sequencing (NGS) should be used for this evaluation. Moreover, co-occurring mutations have an impact on tumor behavior and may influence future therapeutic decision-making.

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Objectives: The shape is commonly used to describe the objects. State-of-the-art algorithms in medical imaging are predominantly diverging from computer vision, where voxel grids, meshes, point clouds, and implicit surface models are used. This is seen from the growing popularity of ShapeNet (51,300 models) and Princeton ModelNet (127,915 models).

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Parkinson's disease (PD) epidemiology and clinical features are sexually dimorphic. However, there are no data based on EEG functional connectivity (FC). Likewise, the contribution of sex hormones on brain FC has never been evaluated.

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Article Synopsis
  • The global use of long-acting reversible contraceptives (LARCs) is rising because they more effectively prevent unintended pregnancies compared to short-acting methods, especially in teens.
  • LARCs include options like intrauterine devices and subcutaneous implants, with specialized training required for their application.
  • This Expert Opinion focuses on the etonogestrel (ENG)-releasing implant, offering updated guidance on insertion, removal, and managing unscheduled bleeding based on extensive clinical experience.
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Background: Rapid eye movement (REM) sleep behavior disorder (RBD) may precede motor symptoms in Parkinson's disease (PD) by years. According to a recent hypothesis, premotor RBD (pRBD) is a marker of the PD body-first subtype, where synucleinopathy originates from the peripheral autonomic nervous system. Conversely, in the brain-first subtype, pathology would arise in the brain.

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Introduction: Our study aimed to identify relevant features associated with the reprisal of antineoplastic treatment in patients with solid cancers after unplanned admittance to the intensive care unit (ICU) and to assess 60th-month survival in patients with solid neoplasms admitted to the ICU.

Methods: This single-centre retrospective study of critically ill patients with active cancers was performed over a 13-year period (2005-2018). Patients' characteristics, overall survival, and antineoplastic treatment reprisal were extracted from digital medical files and compared.

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Lithium metal anode batteries have attracted significant attention as a promising energy storage technology, offering a high theoretical specific capacity and a low electrochemical potential. Utilizing lithium metal as the anode material can substantially increase energy density compared with conventional lithium-ion batteries. However, the practical application of lithium metal anodes has encountered notable challenges, primarily due to the formation of dendritic structures during cycling.

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Heat shock protein family B (small) member 8 (HSPB8) is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock proteins. HSPB8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation, cell division, and migration. HSPB8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective autophagy.

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Article Synopsis
  • - Patients aged 65 and older have a higher risk of cardiovascular (CV) events, and this study aimed to evaluate the effectiveness of stress cardiac magnetic resonance (CMR) for predicting these events in this age group across multiple centers in the U.S.
  • - The research involved 1,780 seniors, finding that those with inducible ischemia or late gadolinium enhancement (LGE) showed significantly higher rates of serious CV events over nearly 5 years, while those without these conditions had a low event rate.
  • - The study concluded that both inducible ischemia and LGE are strong predictors of primary and secondary CV outcomes, indicating that CMR can be a valuable tool for risk assessment in older patients.
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The use of companion diagnostics has become a standard in precision oncology in the context of ongoing therapeutic innovation. However, certain limitations make their application imperfect in current practice. This position paper underscores the need to broaden the notion of companion testing, considering the potential of emerging technologies, including computational biology, to overcome these limitations.

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Mutations targeting distinct domains of the neuron-specific kinesin KIF5A associate with different neurodegenerative/neurodevelopmental disorders, but the molecular bases of this clinical heterogeneity are unknown. We characterised five key mutants covering the whole spectrum of KIF5A-related phenotypes: spastic paraplegia (SPG, R17Q and R280C), Charcot-Marie-Tooth disease (CMT, R864*), amyotrophic lateral sclerosis (ALS, N999Vfs*40), and neonatal intractable myoclonus (NEIMY, C975Vfs*73) KIF5A mutants. CMT-R864*-KIF5A and ALS-N999Vfs*40-KIF5A showed impaired autoinhibition and peripheral localisation accompanied by altered mitochondrial distribution, suggesting transport competence disruption.

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Lysosomes are acidic organelles involved in crucial intracellular functions, including the degradation of organelles and protein, membrane repair, phagocytosis, endocytosis, and nutrient sensing. Given these key roles of lysosomes, maintaining their homeostasis is essential for cell viability. Thus, to preserve lysosome integrity and functionality, cells have developed a complex intracellular system, called lysosome quality control (LQC).

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Article Synopsis
  • CD8 T cells are crucial for controlling tumors but often become dysfunctional in the tumor environment; sodium chloride (NaCl) has been found to counteract this dysfunction and promote cancer regression.
  • Supplementing NaCl during CD8 T cell culture enhances their activation and effectiveness while preserving key gene networks associated with T cell plasticity, leading to improved anti-tumor responses in mouse models.
  • The research suggests that NaCl affects CD8 T cell function by boosting their glutamine consumption, which is essential for their overall effectiveness, indicating potential new strategies for enhancing cancer immunotherapy in humans.
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Article Synopsis
  • Regorafenib is an oral medication used to treat certain types of tumors, including metastatic gastrointestinal stromal tumors (GIST), and is typically considered after other treatments fail.
  • In a case involving a 58-year-old woman, regorafenib was linked to increased levels of red blood cells and hemoglobin, which is not a commonly reported side effect of this drug.
  • The case suggests that the observed increase in red blood cell counts may not be related to dosage but could indicate the drug's effectiveness, highlighting the need for monitoring blood levels in patients on regorafenib.
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Background: Early invasive revascularization guided by moderate to severe ischemia did not improve outcomes over medical therapy alone, underlying the need to identify high-risk patients for a more effective invasive referral. CMR could determine the myocardial extent and matching locations of ischemia and infarction.

Objectives: This study sought to investigate if CMR peri-infarct ischemia is associated with adverse events incremental to known risk markers.

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Autonomic symptoms in Parkinson's disease result from variable involvement of the central and peripheral systems, but many aspects remain unclear. The analysis of functional connectivity has shown promising results in assessing the pathophysiology of Parkinson's disease. This study aims to investigate the association between autonomic symptoms and cortical functional connectivity in early Parkinson's disease patients using high-density EEG.

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Background: The diagnosis of coronary microvascular disease (CMVD) remains challenging. Perfusion PET-derived myocardial blood flow (MBF) reserve (MBFR) can quantify CMVD but is not widely available. Thrombolysis in Myocardial Infarction (TIMI) frame count (TFC) is an angiography-based method that has been proposed as a measure of CMVD.

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Unlabelled: The aim of this study was to assess the potential value of circulating active and inactive IL-18 levels in distinguishing pseudo and true tumor progression among NSCLC patients receiving immune checkpoint inhibitor treatments (ICIs).

Methods: This ancillary study includes 195 patients with metastatic non-small-cell lung cancer (NSCLC) treated with ICI in monotherapy, either pembrolizumab or nivolumab. Plasmatic levels of IL-18-related compounds, comprising the inhibitor IL-18 binding protein (IL-18BP), the inactive IL-18 (corresponding to IL-18/IL-18BP complex), and the active free IL-18, were assayed by ELISA.

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Aim: To determine the long-term prognosis of immune-related response profiles (pseudoprogression and dissociated response), not covered by conventional PERCIST criteria, in patients with non-small-cell lung cancer (NSCLC) treated with immune checkpoint inhibitors (ICPIs).

Methods: 109 patients were prospectively included and underwent [F]FDG-PET/CT at baseline, after 7 weeks (PET1), and 3 months (PET2) of treatment. On PET1, tumor response was assessed using standard PERCIST criteria.

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In recent years, climate change has led to higher grape must sugar content and, consequently, increased alcohol by volume. Evaporative or pertraction is a common method for post-fermentation ethanol removal from wines, but it selectively removes some less polar volatile compounds along with ethanol. To mitigate volatile substance loss, this study investigates blending of the red wine (Marzemino-Cabernet blend) with obtained dealcoholized samples from it by industrial evaporative pertraction system, while maintaining the final product within a two-percentage-point reduction in ethanol.

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