Publications by authors named "Ferrari P"

Background: Ultra-processed food (UPF) consumption has been linked with higher risk of mortality. This multi-centre study investigated associations between food intake by degree of processing, using the Nova classification, and all-cause and cause-specific mortality.

Methods: This study analyzed data from the European Prospective Investigation into Cancer and Nutrition.

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Polyphenols, natural compounds abundant in phenolic structures, have received widespread attention due to their antioxidant, anti-inflammatory, antibacterial, and anticancer properties, making them valuable for biomedical applications. However, the green synthesis of polyphenol-based materials with economical and environmentally friendly strategies is of great significance. In this study, a multifunctional wound dressing was achieved by introducing polyphenol-based materials of copper phosphate-tannic acid with a flower-like structure (Cu-TA NFs), which show the reactive oxygen species scavenging performance.

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High-energy nuclear collisions create a quark-gluon plasma, whose initial condition and subsequent expansion vary from event to event, impacting the distribution of the eventwise average transverse momentum [P([p_{T}])]. Disentangling the contributions from fluctuations in the nuclear overlap size (geometrical component) and other sources at a fixed size (intrinsic component) remains a challenge. This problem is addressed by measuring the mean, variance, and skewness of P([p_{T}]) in ^{208}Pb+^{208}Pb and ^{129}Xe+^{129}Xe collisions at sqrt[s_{NN}]=5.

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  • Previous models for predicting weight gain haven't been very effective, leading researchers to explore both traditional environmental factors and genetic markers to enhance accuracy.* -
  • A study involving nearly 246,000 participants found that environmental factors provided good predictive ability for weight gain, while genetic models performed poorly, especially at mid-late adulthood.* -
  • The research suggests that environmental factors should be incorporated into prevention strategies, and that genetic factors may be more relevant in predicting weight gain earlier in life.*
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  • - This study examines the link between long-term alcohol consumption patterns and the risk of breast cancer in postmenopausal women, using data from nearly 29,000 women aged 50-65 from a Danish cohort.
  • - Researchers identified four different alcohol consumption profiles and found that women whose average intake exceeded 10g per day had a significantly higher risk of developing breast cancer compared to those who consumed less than 6g per day.
  • - The findings show that a consistent high alcohol intake throughout adulthood increased breast cancer risk, while women with lower alcohol intake during early adulthood who later increased their consumption did not show a higher risk compared to those with consistently low intake.
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  • Diffuse large B-cell lymphoma (DLBCL) is a serious type of cancer where the current treatment, R-CHOP, cures only about 60% of patients, prompting the need for improved therapies.
  • Researchers investigated the combination of the FDA-approved PDE4 inhibitor roflumilast with R-CHOP in high-risk, treatment-naïve DLBCL patients, which showed safety and encouraging outcomes, with 70% of patients alive and disease-free at 44 months.
  • Initial results indicate that roflumilast could enhance cancer treatment by inhibiting certain cancer-related signals and may be especially effective for specific high-risk genetic subtypes of DLBCL, suggesting further testing is needed.
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Alcohol consumption is an established cause of female breast cancer. This systematic review examines in detail the association between alcohol and female breast cancer overall and among the described subgroups, using all of the evidence to date. A systematic review of PubMed and Embase was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.

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  • - Tracheobronchial injuries are serious and often misdiagnosed; larger injuries are harder to heal, leading to a variety of treatment options.
  • - A case of a 63-year-old man with a severe 4-cm tracheobronchial tear post-surgery was effectively treated with conservative measures including oxygen, pain management, antibiotics, and nutritional support.
  • - The patient healed completely in four weeks with no complications, highlighting that conservative treatment can be a successful approach for significant tracheal injuries, especially in older patients with other health issues.
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Background: Nutri-Score is a scientifically validated 5-color front-of-pack nutrition label reflecting the nutrient profile of foods. It has been implemented in several European countries on a voluntary basis, pending the revision of the European labeling regulation. Hence, scientific evidence is needed regarding the ability of the nutrient profile underlying the Nutri-Score (uNS-NPS, 2023-updated version) to characterize healthier foods.

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A search for the exclusive hadronic decays W^{±}→π^{±}γ, W^{±}→K^{±}γ, and W^{±}→ρ^{±}γ is performed using up to 140  fb^{-1} of proton-proton collisions recorded with the ATLAS detector at a center-of-mass energy of sqrt[s]=13  TeV. If observed, these rare processes would provide a unique test bench for the quantum chromodynamics factorization formalism used to calculate cross sections at colliders. Additionally, at future colliders, these decays could offer a new way to measure the W boson mass through fully reconstructed decay products.

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  • - The ATLAS experiment at the LHC conducted a search for long-lived particles (LLPs) using a large dataset (140 fb^{-1}) from proton-proton collisions at 13 TeV, focusing on LLPs with masses from 5 to 55 GeV that decay within the inner detector.
  • - The study considered scenarios where LLPs are produced from exotic Higgs boson decays and models involving axionlike particles (ALPs).
  • - No significant findings above expected background levels were detected, leading to the establishment of upper limits on various production rates involving the Higgs boson and the top quark related to LLPs and ALPs.
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  • The study investigates the associated production of Higgs and W bosons, focusing on how the relative signs of the Higgs couplings to W and Z bosons impact the process.
  • Two specific searches were conducted using large amounts of collision data from the LHC to analyze different coupling scenarios: one for opposite-sign couplings and another for same-sign (standard model-like) couplings.
  • The results significantly exclude the opposite-sign coupling hypothesis and set a strict upper limit on the production rate of this process compared to standard model predictions.
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  • * No significant associations were found between individual metabolites or patterns and overall prostate cancer risk after adjusting for multiple tests, except for six specific phosphatidylcholines linked to advanced cases diagnosed within 10 years.
  • * Two metabolite patterns (1 and 2) showed inverse associations with advanced prostate cancer, while pattern 3 was related to prostate cancer death, indicating that metabolite profiles may change several years before advanced disease is detected.
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Advanced models of the brain have evolved in recent years from traditional two-dimensional (2D) ones, based on rodent derived cells, to three-dimensional (3D) ones, based on human neurons derived from induced pluripotent stem cells. To address the dynamic changes of the tissue microenvironment, bioreactors are used to control the microenvironment for viability, repeatability, and standardization. However, in neuronal tissue engineering, bioreactors have primarily been used for cell expansion purposes, while microfluidic systems have mainly been employed for culturing organoids.

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  • South American countries recommend annual influenza vaccination for high-risk groups, including young children, those with preexisting health conditions, and older adults, to reduce morbidity and mortality.
  • Interim estimates from a study conducted in March-July 2024 showed that out of 11,751 influenza-associated severe acute respiratory illness cases, 21.3% of patients were vaccinated, with an adjusted vaccine effectiveness (VE) of 34.5% against hospitalization.
  • The vaccine was particularly effective against subtype A(H3N2) at 36.5% and A(H1N1)pdm09 at 37.1%, indicating that Northern Hemisphere countries should prepare for robust vaccination campaigns and early
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This Letter presents results from a combination of searches for Higgs boson pair production using 126-140  fb^{-1} of proton-proton collision data at sqrt[s]=13  TeV recorded with the ATLAS detector. At 95% confidence level (CL), the upper limit on the production rate is 2.9 times the standard model (SM) prediction, with an expected limit of 2.

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This Letter presents the first study of the energy dependence of diboson polarization fractions in WZ→ℓνℓ^{'}ℓ^{'}(ℓ,ℓ^{'}=e,μ) production. The dataset used corresponds to an integrated luminosity of 140  fb^{-1} of proton-proton collisions at a center-of-mass energy of 13 TeV recorded by the ATLAS detector. Two fiducial regions with an enhanced presence of events featuring two longitudinally polarized bosons are defined.

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This review delves into the remarkable career and scientific contributions of Frans de Waal, a renowned figure in the field of ethology, primatology with important implications for the field of social neurosciences. Rooted in the Dutch tradition of ethology, influenced by luminaries like Niko Tinbergen and Jan Van Hooff, De Waal's career began with groundbreaking research on chimpanzees, which questioned long-held beliefs about dominance and aggression in animal behavior. His work, epitomized in his influential books, such as "Chimpanzee Politics", "The ape and the sushi master", "The age of empathy", not only revolutionized scientific thinking but also ignited discussions about empathy, morality, and complex cognitive functions in animals.

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To assess the presence of oxygen-containing polycyclic aromatic hydrocarbons (OPAHs) in the interstellar medium and understand how water aggregates on an OPAH surface, we present a comprehensive gas-phase spectroscopy investigation of the OPAH xanthene (CHO) and its complexes with water using IR-UV ion dip spectroscopy and chirped-pulse Fourier transform microwave spectroscopy. The infrared spectrum of xanthene shows weak features at 3.42, 3.

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The global impacts of pulmonary hypertension (PH) were formally recognised in 1973 at the 1st World Health Organization meeting dedicated to primary pulmonary hypertension, held in Geneva. Investigations into disease pathogenesis and classification led to the development of numerous therapies over the ensuing decades. While the impacts of the disease have been lessened due to treatments, the symptoms and adverse effects of PH and its therapies on patients' wellbeing and mental health remain significant.

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  • * The study investigates an innovative electrospun scaffold made from poly(caprolactone) and poly(glycerol sebacate) with added quercetin and gelatin, evaluated in a custom bioreactor mimicking human physiological conditions.
  • * Results showed that the scaffolds maintained suitable mechanical properties, effectively released bioactives to manage inflammation and permeability, making them promising candidates for in vivo vascular applications.
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Background: Food biodiversity in human diets has potential co-benefits for both public health and sustainable food systems. However, current evidence on the potential relationship between food biodiversity and cancer risk, and particularly gastrointestinal cancers typically related to diet, remains limited. This study evaluated how dietary species richness (DSR) was associated with gastrointestinal cancer risk in a pan-European population.

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The retention capacity of polymers is related to the development of systems that combine high surface-to-volume ratio with good handling and specific functionality. Biodegradability and biocompatibility are also key features for extending the field of applications to areas such as biomedicine. With this in mind, the aim of this work is to develop biodegradable, biocompatible, and highly functionalized porous films, that ensure suitable handling and a good surface-to-volume ratio.

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Metabolic reprogramming is a k`ey hallmark of tumors, developed in response to hypoxia and nutrient deficiency during tumor progression. In both cancer and immune cells, there is a metabolic shift from oxidative phosphorylation (OXPHOS) to aerobic glycolysis, also known as the Warburg effect, which then leads to lactate acidification, increased lipid synthesis, and glutaminolysis. This reprogramming facilitates tumor immune evasion and, within the tumor microenvironment (TME), cancer and immune cells collaborate to create a suppressive tumor immune microenvironment (TIME).

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