Publications by authors named "Ferran Gomez-Castro"
Article Synopsis
- - The formation of neural circuits depends on stabilizing active GABAergic synapses while eliminating inactive ones; this process involves both GABA type A receptors (GABARs) and adenosine A receptors (ARs).
- - Activation of postsynaptic GABARs and ARs works together to produce adenosine 3′,5′-monophosphate through a calcium–calmodulin–adenylyl cyclase pathway, which then activates protein kinase A to stabilize the synapses.
- - The study suggests that ARs help identify active GABAergic synapses by responding to GABA and other molecules, influencing whether these synapses are stabilized or removed.
The K-Cl co-transporter KCC2 (SLC12A5) tunes the efficacy of GABA receptor-mediated transmission by regulating the intraneuronal chloride concentration [Cl]. KCC2 undergoes activity-dependent regulation in both physiological and pathological conditions. The regulation of KCC2 by synaptic excitation is well documented; however, whether the transporter is regulated by synaptic inhibition is unknown.
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