Publications by authors named "Ferran Araujo-Ayala"

Follicular lymphoma (FL), the most common indolent non-Hodgkin lymphoma, constitutes a paradigm of immune tumor microenvironment (TME) contribution to disease onset, progression, and heterogenous clinical outcome. Here we present the first FL-Patient Derived Lymphoma Spheroid (FL-PDLS), including fundamental immune actors and features of TME in FL lymph nodes (LNs). FL-PDLS is organized in disc-shaped 3D structures composed of proliferating B and T cells, together with macrophages with an intermediate M1/M2 phenotype.

View Article and Find Full Text PDF

Mantle cell lymphoma (MCL), a rare and aggressive B-cell non-Hodgkin lymphoma, mainly develops in the lymph node (LN) and creates a protective and immunosuppressive niche that facilitates tumor survival, proliferation and chemoresistance. To capture disease heterogeneity and tumor microenvironment (TME) cues, we have developed the first patient-derived MCL spheroids (MCL-PDLS) that recapitulate tumor oncogenic pathways and immune microenvironment in a multiplexed system that allows easy drug screening, including immunotherapies. MCL spheroids, integrated by tumor B cells, monocytes and autologous T-cells self-organize in disc-shaped structures, where B and T-cells maintain viability and proliferate, and monocytes differentiate into M2-like macrophages.

View Article and Find Full Text PDF

Follicular lymphoma (FL) is a paradigm of tumors that require the interaction between tumor and microenvironment cells to foster their development from initial steps to progression. Recent large-scale genome studies have uncovered multiple genetic alterations of FL that influence the microenvironment in two main directions, promoting tumor cell survival and proliferation and facilitating their evasion from immune antitumor signals. Understanding the crosstalk between tumor B-cells and the microenvironment will facilitate the identification of vulnerabilities that may offer novel targets for treatment of the patients.

View Article and Find Full Text PDF
Article Synopsis
  • - Follicular Lymphoma (FL) is the most common slow-growing non-Hodgkin's B cell lymphoma and heavily relies on its immune microenvironment for growth and variation in disease behavior.
  • - Advanced technologies such as whole-exome sequencing and single-cell RNA sequencing have allowed researchers to understand the specific cell types in the FL environment and how recurring mutations affect tumor progression and microenvironment interactions.
  • - This understanding has led to the development of new therapies that aim to disrupt the supportive relationship between FL and its microenvironment, enhancing the body's immune response against the lymphoma.
View Article and Find Full Text PDF