Regulation of peripheral glucose levels during human sleep.

Studies in rats indicate that oscillatory signatures of memory processing during sleep, and specifically hippocampal sharp wave-ripples, also regulate peripheral glucose concentration. Here, we examined whether there is a similar link between such signatures of memory processing and glucose regulation during sleep in healthy humans. We obtained polysomnographic recordings and continuous recordings of peripheral interstitial glucose levels (1 sample/min) from 10 participants (5 females) during two consecutive nights.