Publications by authors named "Fernando Scudiero"
Article Synopsis
- - The study aims to compare immediate versus staged percutaneous coronary intervention (PCI) strategies for patients with aneurysmatic right coronary artery (ARCA) during acute coronary syndrome (ACS), analyzing outcomes from 85 patients.
- - Results show that both PCI strategies had similar rates of procedural success and long-term outcomes, but the staged approach led to a higher incidence of bleeding and longer hospital stays.
- - The findings suggest that while both methods are viable, immediate PCI might be preferable due to lower complications and shorter hospital duration.
Article Synopsis
- A multicenter study analyzed the effectiveness and safety of intravenous antiplatelet therapies, cangrelor and tirofiban, in STEMI patients undergoing PPCI at seven Italian centers.
- The primary outcome measured was the incidence of TIMI flow < 3 after the procedure and the risk of bleeding (BARC 2-5) in patients receiving either treatment.
- Results showed that cangrelor led to better myocardial blood flow post-PPCI compared to tirofiban, without a higher risk of significant bleeding complications.
Aims: The aim of this study was to investigate the long-term outcome of takotsubo syndrome (TTS) patients with and without hypertension (HT) and to evaluate the effectiveness of treatment with beta-blockers (BBs) and/or renin-angiotensin-aldosterone system inhibitors (RAASi).
Methods And Results: The study population includes a register-based, multicentre cohort of consecutive patients with TTS, divided into two groups according to the history of HT. Further stratification was performed for BB/RAASi prescription at discharge.
Hepatitis C virus (HCV) is one of the leading causes of chronic liver disease affecting over 71 million people worldwide. An increased incidence of atherothrombotic events [e.g.
View Article and Find Full Text PDFBackground: This study is aimed at comparing the clinical outcomes of unprotected left main coronary artery disease (ULMCAD) treatment with contemporary percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) in a "real-world" population.
Methods And Results: Overall, 558 consecutive patients with ULMCAD (mean age 71 ± 9 years, male gender 81%) undergoing PCI or CABG were compared. The primary endpoint was the composite of death, nonfatal myocardial infarction, or stroke.
Article Synopsis
- The study aimed to assess the long-term benefits of beta-blocker treatment in patients recovering from Takotsubo syndrome (TTS) after discharge, considering the impact of catecholamines on the condition.
- Conducted across multiple centers, the research involved 825 patients diagnosed with TTS, comparing outcomes between those who were prescribed beta-blockers and those who weren't over a median follow-up period of 24 months.
- Results indicated that patients on beta-blockers had significantly lower risks of all-cause and non-cardiac death, particularly benefiting those with hypertension or cardiogenic shock during the acute phase of TTS.
Article Synopsis
- Pre-existing atrial fibrillation (AF) is common in COVID-19 patients and the study aimed to determine its impact on disease severity and mortality.
- Out of 467 hospitalized COVID-19 patients, 26.1% had a history of AF, with most cases being persistent or permanent in nature.
- The study found that while pre-existing AF increased the risk of developing severe acute respiratory distress syndrome (ARDS), it did not significantly affect the risk of in-hospital mortality.
Article Synopsis
- - The study focused on assessing the long-term clinical outcomes of hospitalized COVID-19 patients, specifically examining the relationship between right ventricular (RV) dysfunction and 1-year mortality rates in a cohort of 224 patients from seven hospitals in Italy.
- - RV dysfunction was found in 28% of patients; those affected were older, had a higher prevalence of coronary artery disease, and lower heart function compared to those without RV dysfunction.
- - The research concluded that patients with RV dysfunction had significantly higher 1-year mortality rates (67% vs. 28%) and indicated that RV dysfunction is a common issue in COVID-19 patients, correlating with increased long-term mortality risk.
Article Synopsis
- The study investigates how body mass index (BMI) affects platelet reactivity in patients with ST-Elevation Myocardial Infarction (STEMI) who are treated with oral 3rd generation P2Y inhibitors.
- It involved 429 STEMI patients, dividing them based on BMI (<25 vs ≥25 kg/m) and using a method to balance their baseline characteristics, followed by multiple assessments of platelet reactivity at various times post-treatment.
- The results showed that patients with a BMI of 25 or higher had higher platelet reactivity shortly after treatment and were more likely to experience high platelet reactivity, indicating that higher BMI may delay the response to these medications in the short term.
Aims: Pulmonary involvement in Coronavirus disease 2019 (COVID-19) may affect right ventricular (RV) function and pulmonary pressures. The prognostic value of tricuspid annular plane systolic excursion (TAPSE), systolic pulmonary artery pressure (PAPS), and TAPSE/PAPS ratios have been poorly investigated in this clinical setting.
Methods And Results: This is a multicenter Italian study, including consecutive patients hospitalized for COVID-19.
Little is known about the predictors recurrent ischemic events in patients with ST-segment elevation myocardial infarction (STEMI). This study aimed at investigating the predictors of recurrent myocardial infarction (MI) at long-term follow-up in a real-world STEMI cohort. All consecutive STEMI patients who underwent emergent coronary angiography and primary percutaneous coronary intervention between February 2013 and June 2019 at our institution were included.
View Article and Find Full Text PDFBackground: Coronavirus disease 2019 (COVID-19) is a recently recognized viral infective disease which can be complicated by acute respiratory stress syndrome (ARDS) and cardiovascular complications including severe arrhythmias, acute coronary syndromes, myocarditis and pulmonary embolism. The aim of the present study was to identify the clinical conditions and echocardiographic parameters associated with in-hospital mortality in COVID-19.
Methods: This is a multicentre retrospective observational study including seven Italian centres.
Statin therapy has been recently suggested as possible adjuvant treatment to improve the clinical outcome in patients with coronavirus disease 2019 (COVID-19). The aim of this study was to describe the prevalence of preadmission statin therapy in hospitalized patients with COVID-19 and to investigate its potential association with acute distress respiratory syndrome (ARDS) at admission and in-hospital mortality. We retrospectively recruited 467 patients with laboratory-confirmed COVID-19 admitted to the emergency department of 10 Italian hospitals.
View Article and Find Full Text PDFPurpose: The clinical course of COVID-19 may be complicated by acute respiratory distress syndrome (ARDS) and thromboembolic events, which are associated with high risk of mortality. Although previous studies reported a lower rate of death in patients treated with heparin, the potential benefit of chronic oral anticoagulation therapy (OAT) remains unknown. We aimed to investigate the association between OAT with the risk of ARDS and mortality in hospitalized patients with COVID-19.
View Article and Find Full Text PDFPlatelet reactivity (PR) has been indicated as a pathophysiological key element for ST-Elevation Myocardial Infarction (STEMI) development. Patients with not-high before-treatment platelet reactivity (NHPR) have been poorly studied so far. The aim of this study is to investigate the prevalence, clinical characteristics, response to therapy and outcomes of baseline prior to treatment NHPR among patients with STEMI undergoing primary PCI.
View Article and Find Full Text PDFBackground: Despite the fast-growing understanding of the coronavirus disease 2019 (COVID-19), patient management remains largely empirical or based on retrospective studies. In this complex scenario, an important clinical issue appears to be represented by the high prevalence of thromboembolic events, but the data regarding high-risk pulmonary embolism (PE) is still not available.
Case Summary: A patient with COVID-19 developed sudden shortness of breath and hypoxia.
Introduction: The incidence, characteristics, and prognosis of pulmonary embolism (PE) in Coronavirus disease 2019 (COVID-19) have been poorly investigated. We aimed to investigate the prevalence and the correlates with the occurrence of PE as well as the association between PE and the risk of mortality in COVID-19.
Methods: Retrospective multicenter study on consecutive COVID-19 patients hospitalized at 7 Italian Hospitals.
Article Synopsis
- Coronary artery disease (CAD) is a serious risk for patients with Hepatitis C Virus (HCV) infection, particularly affecting those with acute coronary syndrome (ACS).
- A study found that HCV-infected patients had significantly higher platelet reactivity and severity of CAD compared to non-infected patients, which led to worse long-term cardiovascular outcomes.
- The analysis also revealed that having HCV was an independent risk factor for high platelet reactivity, more severe CAD, and increased rates of major adverse cardiovascular events and bleeding complications.
Introduction: Little is still known about the prognostic impact of incident arrhythmias in hospitalized patients with COVID-19. The aim of this study was to evaluate the incidence and predictors of sustained tachyarrhythmias in hospitalized patients with COVID-19, and their potential association with disease severity and in-hospital mortality.
Materials And Methods: This was a retrospective multicenter observation study including consecutive patients with laboratory confirmed COVID-19 admitted to emergency department of ten Italian Hospitals from 15 February to 15 March 2020.
Background: Currently, the use of advanced ventricular support systems during percutaneous mitral valve repair (PMVR) procedures is confined to very few selected cases in emergency or bailout situations. No cases are reported of planned use of ventricular support devices in the subgroup of high-risk patients undergoing PMVR.
Case Summary: We report two cases of planned and 'protected' procedures of PMVR with Impella CP mechanical circulatory support.
Little is still known about the clinical features associated with the occurrence of acute respiratory distress syndrome (ARDS) in hospitalized patients with Coronavirus disease 2019 (COVID-19). The aim of the present study was to describe the prevalence of pre-admission antithrombotic therapies in patients with COVID-19 and to investigate the potential association between antithrombotic therapy and ARDS, as disease clinical presentation, or in-hospital mortality. We enrolled 192 consecutive patients with laboratory-confirmed COVID-19 admitted to emergency department of five Italian hospitals.
View Article and Find Full Text PDF