Publications by authors named "Fernando Salvati"
Article Synopsis
- Morphometry of striated muscle fibres is important for assessing muscle health, and this study used the MusMA tool to analyze muscle function in two models: collagen-induced arthritis for skeletal muscle and non-alcoholic fatty liver disease for cardiac muscle.
- After studying muscle segments stained with specific dyes, researchers classified muscle fibres into various categories, revealing links between fibre types and functional performance measures such as walking speed and grip strength.
- The findings indicate that normal muscle fibres are associated with better physical function and lower cardiovascular risks, suggesting that MusMA could be a valuable tool in diagnosing muscle diseases and researching their functional implications.
The muscle fiber morphometric analysis (MusMA) is a protocol to segment and characterize the morphometry of individual cross-sectioned striated muscle fibers. Using a semi-automated Excel spreadsheet, the protocol allows the objective measurement of muscle fibers' subpopulations, aiming to characterize physiopathological conditions related to muscle tissue. The main limitation of MusMA is the need for high-quality tissue slides and images and control samples to set up the analyses.
View Article and Find Full Text PDFBackground: Cardiovascular disease is the main cause of death in metabolic-associated fatty liver disease, and gut microbiota dysbiosis is associated with both of them.
Aim: To assess the relationship between gut dysbiosis and cardiovascular risk (CVR) in an experimental model of steatohepatitis.
Methods: Adult male Sprague-Dawley rats were randomized to a control group ( = 10) fed a standard diet and an intervention group ( = 10) fed a high-fat choline-deficient diet for 16 wk.