Coronary flow reserve (CFR) is a well-validated flow-based physiological parameter that has shown value in clinical risk stratification. CFR can be invasively assessed, classically by Doppler and, more recently, by thermodilution with saline boluses (CFR). Alternatively, continuous thermodilution is a novel operator-independent, highly-reproducible technique to invasively quantify maximum absolute coronary flow (AF).
View Article and Find Full Text PDFCatheter Cardiovasc Interv
August 2018
Objectives: To compare the safety and efficacy of the new cobalt-chromium bioactive stent Titan Optimax (Hexacath, France) with its predecessor, Titan-2 .
Background: The TIOMAX registry includes 784 patients who underwent percutaneous coronary intervention with these stents in 21 Spanish hospitals.
Methods: Analysis of all patients in the registry without exclusion criteria, candidates for revascularization (March-2013/July-2014).
Objectives: We performed a post hoc analysis of outcome in patients with, versus those without, calcified target lesions from the BASE ACS trial.
Background: The outcome of contemporary stent implantation in patients with calcified lesions presenting with acute coronary syndrome is unknown.
Methods: The BASE ACS trial randomized 827 patients (1:1) presenting with acute coronary syndrome to receive either titanium-nitride-oxide-coated stents or everolimus-eluting stents.
Background: The BASE ACS randomized trial demonstrated non-inferiority of titanium-nitride-oxide-coated bioactive stents (BAS), compared with everolimus-eluting stents (EES), for the primary endpoint of major adverse cardiac events (MACE) in patients presenting with acute coronary syndrome (ACS) at 12-month follow-up. We report the final long-term clinical outcome of the trial.
Methods: We randomly assigned 827 patients with ACS to receive either BAS (417) or EES (410).
Objectives: The BASE-ACS trial demonstrated non-inferiority of titanium-nitride-oxide-coated bioactive stents (BAS), versus everolimus-eluting stents (EES), for major adverse cardiac events (MACE) at 1- and 2-year follow-up, in patients with acute coronary syndrome (ACS). We presented the 4-year outcome of the BASE-ACS trial.
Design: We randomized 827 patients with ACS to receive either BAS (417) or EES (410).
Rev Esp Cardiol (Engl Ed)
October 2015
Introduction And Objectives: The recommendation for dual antiplatelet therapy following drug-eluting stent implantation ranges from 6 months to 12 months or beyond. Recent trials have suggested the safety of a 6-month dual antiplatelet therapy regimen, yet certain caveats to these studies limit the applicability of this shorter duration dual antiplatelet therapy strategy in real world settings.
Methods: A registry was constructed with consecutive recruitment of patients undergoing new-generation drug-eluting stent implantation and prescribed 6 months of dual antiplatelet therapy.
Ann Med
November 2013
Background: The BASE-ACS trial demonstrated an outcome of the titanium-nitride-oxide-coated bioactive stents (BAS) statistically non-inferior to that of the everolimus-eluting stents (EES) at 12-month follow-up in patients presenting with acute coronary syndrome (ACS). We performed a post hoc analysis of the BASE-ACS trial with particular focus on stent-oriented versus patient-oriented outcome at 24-month follow-up.
Methods: A total of 827 patients with ACS were randomly assigned to receive either BAS (417) or EES (410).
Aims: Titanium-nitride-oxide-coated bioactive stents (BAS) have demonstrated a favourable outcome when compared with paclitaxel-eluting stents in patients with acute myocardial infarction (MI). In a prospective randomised non-inferiority study design, we compared the safety and efficacy of BAS versus everolimus-eluting stents (EES) in patients with acute coronary syndrome (ACS).
Methods And Results: We randomised 827 patients with ACS (1:1) to either BAS (417) or EES (410).