Publications by authors named "Fernando Ramirez-Jimenez"
Article Synopsis
- The study aimed to assess lung function and asthma control in patients with Non-Exacerbated Respiratory Disease (N-ERD) over three years, following GINA guidelines.
- At baseline, N-ERD patients showed better lung function and required lower doses of inhaled corticosteroids compared to traditional asthma patients, who relied more on oral corticosteroids.
- By the end of the follow-up, the lung function of traditional asthma patients improved significantly, leading to similar asthma control levels in both groups, but one-third of N-ERD patients continued needing additional medications to maintain control.
Article Synopsis
- The study focuses on the clinical characteristics of DRESS syndrome caused by antituberculosis drugs, analyzing records from patients between 2014 and 2020.
- The research identified 15 cases that exhibited key symptoms like rash, eosinophilia, fever, and kidney/liver damage, with liver issues linked to longer latency periods.
- Findings indicate that this syndrome does not depend on the number of drugs used or the resistance patterns of Mycobacterium tuberculosis, and it responds well to treatment with systemic corticosteroids.
The discovery of the mechanism underlying allergic disease, mouse models of asthma, and bronchoscopy studies provided initial insights into the role of Th2-type cytokines, including interlukin (IL)-4, IL-5 and IL-13, which became the target of monoclonal antibody therapy. Omalizumab, Benralizumab, Mepolizumab, Reslizumab, and Tezepelumab have been approved. These biologicals have been shown to be good alternative therapies to corticosteroids, particularly in severe asthma management, where they can improve the quality of life of many patients.
View Article and Find Full Text PDFVelvet mesquite () is a native legume of the southwestern United States and northwestern Mexico, contributing significantly to the desert ecosystem and playing key ecological roles. It is also an important cause of allergic respiratory disease widely distributed in the Sonoran, Chihuahuan, and Mojave Deserts. However, no allergens from velvet mesquite pollen have been identified to date.
View Article and Find Full Text PDFPurpose: To evaluate the association between allergic sensitivity and pollen counts in patients with allergic respiratory disease (ARD) and its relationship with atmospheric pollutants.
Methods: From 2012 to 2018, we evaluated the sensitivity by skin prick test in ARD patients. The pollen counts were analyzed according to international guidelines (2014-2018).
Allergen immunotherapy (AIT) is the sole disease-modifying treatment for allergic rhinitis; it prevents rhinitis from progressing to asthma and lowers medication use. AIT against mites, insect venom, and certain kinds of pollen is effective. The mechanism of action of AIT is based on inducing immunological tolerance characterized by increased IL-10, TGF-β, and IgG4 levels and Treg cell counts.
View Article and Find Full Text PDFTranscriptome Analysis Identifies Doublesex and Mab-3 Related Transcription Factor (DMRT3) in Nasal Polyp Epithelial Cells of Patients Suffering from Non-Steroidal Anti-Inflammatory Drug-Exacerbated Respiratory Disease (AERD).
Biomolecules
July 2021
Article Synopsis
- AERD is characterized by chronic respiratory issues and aspirin intolerance, linked to an imbalance in eicosanoid metabolism and overproduction of CysLTs.
- Researchers analyzed nasal epithelial cells from AERD patients to identify gene expression patterns, finding significant differences in 20 genes—8 upregulated, including DMRT3.
- DMRT3 may play a role in the development of nasal polyps in AERD, highlighting the need for more research to understand the mechanisms of polyp formation in this condition.
Asthma is a chronic inflammation of lower airway disease, characterized by bronchial hyperresponsiveness. Type I hypersensitivity underlies all atopic diseases including allergic asthma. However, the role of neurotransmitters (NT) and neuropeptides (NP) in this disease has been less explored in comparison with inflammatory mechanisms.
View Article and Find Full Text PDFIntroduction: Subcutaneous allergen-specific immunotherapy (SCIT) is one of the main cornerstones in the treatment of allergic rhinitis in pediatric patients. It has demonstrated symptoms and quality of life improvement, but it is not exempt from adverse reactions (ADVrs). Nevertheless, there are a few reports that have evaluated their safety.
View Article and Find Full Text PDFBackground: Aspirin-exacerbated respiratory disease (AERD) consists of asthma, chronic rhinosinusitis with polyps, and hypersensitivity to aspirin and/or nonsteroidal anti-inflammatory drugs (NSAIDs). Nasal Lysine Aspirin Challenge is an effective tool for the diagnosis of hypersensitivity to aspirin and/or NSAIDs in patients with AERD. However, there is no unified international consensus version to perform nasal provocation tests (NPTs).
View Article and Find Full Text PDFBackground: Allergen immunotherapy (AIT) has a longstanding history and still remains the only disease-changing treatment for allergic rhinitis and asthma. Over the years 2 different schools have developed their strategies: the United States (US) and the European. Allergen extracts available in these regions are adapted to local practice.
View Article and Find Full Text PDFArticle Synopsis
- Non-steroidal anti-inflammatory drugs (NSAID) exacerbated respiratory disease (N-ERD) combines asthma, nasal polyps, and NSAID hypersensitivity, with genetic studies investigating SNPs for potential associations.
- Researchers conducted a two-stage study to evaluate the relationship between specific SNPs and N-ERD in Mexican-mestizo patients, testing 381 selected SNPs across various groups (N-ERD, asthma, control).
- The study identified multiple SNPs associated with N-ERD, with rs1800872 being the only significant SNP linked to the disease in the second stage, suggesting a genetic factor in susceptibility for this population.
Aspirin exacerbated respiratory disease (AERD) is a set of diseases of the unified airway, and its physiopathology is related to disruption of the metabolism of arachidonic acid (AA). Genetic association studies in AERD had explored single nucleotide polymorphism (SNPs) in several genes related to many mechanisms (AA metabolism, inflammation, drug metabolism, etc.) but most lack validation stages in second populations.
View Article and Find Full Text PDFSingle nucleotide polymorphisms in TNF are associated with susceptibility to aspirin-exacerbated respiratory disease but not to cytokine levels: a study in Mexican mestizo population.
Biomark Med
December 2017
Aim: To evaluate the association of three single nucleotide polymorphisms in TNF and one in LTA in Mexican patients with aspirin-exacerbated respiratory disease (AERD) and the correlation of those single nucleotide polymorphisms with serum levels of TNF-α.
Patients & Methods: Case-control study including 133 patients with AERD, 135 patients with asthma (aspirin-tolerant asthmatics) and 182 healthy subjects.
Results: GA genotype of rs1800629 in TNF was found to be associated with the risk of developing AERD (p < 0.
Introduction: Aspirin-exacerbated respiratory disease (AERD) is a clinical entity characterized by hypersensitivity to aspirin leading to asthma and chronic rhinosinusitis with nasosinusal polyposis. The pathophysiology of the disease involves disruption at the level of arachidonic acid metabolism. Therefore, genetic association studies have been focused on the genes coding this pathway.
View Article and Find Full Text PDFBackground: Interleukin (IL) 16 and thymus and activation-regulated cytokine (TARC) are chemoattractant cytokines for eosinophils and T2 cells. Differential levels of these components in aspirin-exacerbated respiratory disease (AERD) and allergic rhinitis with asthma (ARwA) may be related to a different inflammatory response in both asthma phenotypes.
Objective: To assess the nasal lavage immunoreactivity of IL-16 and TARC cytokines.