Publications by authors named "Fernando P Ferraz"
Pediatric overweight, dyslipidemia and insulin resistance can result from unhealthy lifestyle habits and increase morbidity and mortality in adulthood. Herein, we evaluated the relationship between diet and physical activity patterns with the metabolic health of 9-year-old school children. Measurements included anthropometry, adiposity, lipid, and glycemic profiles.
View Article and Find Full Text PDFBackground: Autopsy studies reveal that atherosclerosis lesions can be found as early as two years of age. To slow the development of this early pathology, obesity and dyslipidemia prevention should start from childhood making it urgent to explore new ways to evaluate dyslipidemia risk in children that can be applied widely, such as the non-invasive anthropometric evaluation.
Objective: Assess the metabolic profile of a pediatric population at a specific age to describe the association between anthropometric and biochemical cardiovascular disease risk factors; and evaluate selected anthropometric variables as potential predictors for dyslipidemic cardiovascular risk.
Purpose: Evaluate the relationship of leptin receptor (LEPR) rs1137101, fat mass obesity-associated (FTO) receptors 9939609, melanocortin-4 receptors (MC4R) rs2229616 and rs17782313, and proliferator-activated receptor-gamma (PPARG) rs1801282 with clinical and metabolic phenotypes in prepubertal children.
Research Question: What is the effect of polymorphisms on clinical and metabolic phenotypes in prepubertal children?
Methods: A cross-sectional descriptive study was performed to evaluate anthropometric features, percentage body fat (%BF), biochemical parameters, and genotype in 773 prepubertal children.
Results: FTO rs9939609 was associated with an increase in body mass index (BMI) and BMI z-score (zBMI).
Objective: To develop and cross-validate predictive models for percentage body fat (%BF) from anthropometric measurements [including BMI -score (zBMI) and calf circumference (CC)] excluding skinfold thickness.
Methods: A descriptive study was carried out in 3,084 pre-pubertal children. Regression models and neural network were developed with %BF measured by Bioelectrical Impedance Analysis (BIA) as the dependent variables and age, sex and anthropometric measurements as independent predictors.
Introduction/objectives: Previous experiments suggest that the striatal sensorimotor territory in rats is located in its dorsolateral region, along the rostrocaudal axis, unlike what has been observed in primates. In the present study, electrical stimulation was performed to investigate the degree of participation of the posterior striatum in its motor territory, its somatotopic organization, and the motor responses evoked by stimulation.
Methods: Twenty-five rats were submitted to stereotactic stimulation of the posterior striatum under general anesthesia, receiving consecutively four different current intensities.
Article Synopsis
- The study investigates the hypothesis that essential tremor (ET) may be related to hyperactivity in the posterior putamen, contrasting traditional views that focus on the olivocerebellar system.
- A rat model of ET was used, with groups undergoing either surgery to remove sections of the posterior striatum or sham procedures, followed by administration of harmaline to induce tremors for assessment.
- Results showed significant tremor reduction in the experimental group that had surgery, suggesting the posterior striatum's involvement in ET and supporting the proposed hypothesis.