Publications by authors named "Fernando Ormeno"
The intake of food with high levels of saturated fatty acids (SatFAs) is associated with the development of obesity and insulin resistance. SatFAs, such as palmitic (PA) and stearic (SA) acids, have been shown to accumulate in the hypothalamus, causing several pathological consequences. Autophagy is a lysosomal-degrading pathway that can be divided into macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA).
View Article and Find Full Text PDFTriadimefon (TDF) is a pesticide used in agricultural crops to control powdery mildews, rusts and other fungal pests. It exerts its fungicidal activity through the inhibition of ergosterol biosynthesis, impairing the formation of the cell membrane. For vertebrates, one of its side effects is the binding to the dopamine transporter increasing the levels of synaptic dopamine, similarly to cocaine.
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- TDP-43 is a crucial protein involved in RNA metabolism and is linked to neurodegenerative diseases like ALS and FTLD, where it forms aggregates in neurons.
- Chaperone Mediated Autophagy (CMA) is a pathway that helps degrade proteins, including those associated with neurodegeneration, and can be influenced by protein aggregates.
- The study shows that TDP-43 can be degraded by CMA, with both normal and aggregate-prone forms found in lysosomes, indicating that CMA plays a role in managing TDP-43 levels and its aggregation may disrupt CMA function.
Trypanosoma cruzi, the etiological agent of Chagas' disease, presents three cellular forms (trypomastigotes, epimastigotes and amastigotes), all of which are submitted to oxidative species in its hosts. However, T. cruzi is able to resist oxidative stress suggesting a high efficiency of its DNA repair machinery.
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