SARS-CoV-2 infection negatively affects ovarian function in ART patients.

Several organs, such as the heart, breasts, intestine, testes, and ovaries, have been reported to be target tissues of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. To date, no studies have demonstrated SARS-CoV-2 infection in the female reproductive system. In the present study, we investigated the effects of SARS-CoV-2 infection on ovarian function by comparing follicular fluid (FF) from control and recovered coronavirus disease 2019 (COVID-19) patients and by evaluating the influence of these FF on human endothelial and non-luteinized granulosa cell cultures.

COVID-19 and assisted reproductive technology services: repercussions for patients and proposal for individualized clinical management.

The prolonged lockdown of health services providing high-complexity fertility treatments -as currently recommended by many reproductive medicine entities- is detrimental for society as a whole, and infertility patients in particular. Globally, approximately 0.3% of all infants born every year are conceived using assisted reproductive technology (ART) treatments.

[Antagonists: from physiology to assisted reproduction].

The objective of this article was to make a detailed review of the biological and clinical effects of a relatively new medication: the gonadotropin-releasing hormone antagonists. The GnRH antagonists have had an increasingly consumption since their release in the last three years. This review will discuss current strategies and potential applications for the GnRH antagonists.

Healthy girl born after cryopreservation of gametes and ICSI in a patient with seminoma.

This study reports birth in a case of intracytoplasmic sperm injection with cryopreserved oocytes and spermatozoa banked after radiotherapy and prior to chemotherapy due the occurrence of two non-synchronous seminomas. A 30-year-old male with a diagnosis of seminoma cryopreserved six vials of spermatozoa. After oncological treatment was completed, his partner, a 24-year-old woman, underwent ovarian stimulation.

[A study of two different routes of administration of micronized progesterone in assisted reproduction].

Background: Progesterone is almost completely absorbed after administration by oral route when its preparation is micronized, but, due to the important metabolic inactivation during the first hepatic pass, bioavailability of oral progesterone is notably poor reaching values lesser than 10%.

Objective: To compare two different routes of administration of progesterone for luteal phase support in artificial insemination protocols.

Material And Methods: 24 patients were randomly allocated in the 2 arms of the study, 200 mg/daily, vaginally or p.