[Intellectual developmental disability overlapping with autism spectrum disorder and attention deficit-hyperactivity disorder].

The subject of disabilities that include cognition and adaptability will never cease to be interesting and relevant. The genetic etiology has more weight every day. The relationship with other neurodevelopmental disorders such as autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) is of clinical, diagnostic and therapeutic importance.

Familiality of Co-existing ADHD and Tic Disorders: Evidence from a Large Sibling Study.

Background: The association of attention-deficit/hyperactivity disorder (ADHD) and tic disorder (TD) is frequent and clinically important. Very few and inconclusive attempts have been made to clarify if and how the combination of ADHD+TD runs in families.

Aim: To determine the first time in a large-scale ADHD sample whether ADHD+TD increases the risk of ADHD+TD in siblings and, also the first time, if this is independent of their psychopathological vulnerability in general.

[Emotional self-regulation in infantile attention deficit hyperactivity disorder and P300 evoked potentials].

Introduction: The difficulties that patients with attention deficit hyperactivity disorder (ADHD) have when it comes to emotional regulation have aroused a great deal of interest in recent years and there is a line of research working on the identification of the neurophysiological correlates.

Aims: To analyse measures of emotional functioning and their correlation with the P300 component in a sample of children with ADHD with and without treatment.

Patients And Methods: The sample was made up of 71 children with ADHD, almost half of whom were taking some form of medication.

[Change in the therapeutic strategy when faced with an inadequate response to the pharmacological treatment of attention deficit hyperactivity disorder].

Introduction: Attention deficit hyperactivity disorder (ADHD) is a disorder of a biological origin affecting the neurodevelopment of the brain. It is estimated that 3-7% of school-age children present ADHD. The most commonly used pharmacological treatments are amphetamines and methylphenidate (MPH).

[The P300 component as a neurophysiological correlate of behavioural working memory in adolescents with attention deficit hyperactivity disorder].

Introduction: Deficit in the executive functions has been widely studied in attention deficit hyperactivity disorder (ADHD). The interest in its neurophysiological correlates has led to an improvement in the identification of the symptoms, the characteristics and the treatment of the disorder.

Aims: The objective of this study was to analyse the correlation between latency and amplitude of the P300 component and an ecological measure of working memory in a sample of adolescents.

[Pharmacological management of attention deficit hyperactivity disorder with methylphenidate and atomoxetine within a context of epilepsy].

Introduction: The prevalence of attention deficit hyperactivity disorder (ADHD) in patients with epilepsy stands at around 30-40%, especially the inattentive subtype, while other studies on children diagnosed with ADHD show figures that vary from 6.1% to 30% which present alterations in the electroencephalogram and epilepsy problems. Although clinical practice guidelines advise against treatment with psychostimulants in ADHD that is comorbid with epilepsy, especially when the latter is not considered active, some researchers and practitioners recommend caution as regards beginning this pharmacological therapy, while less research has been conducted on the use of non-psychostimulants.

[Cognitive evoked potentials and executive functions in children with attention deficit hyperactivity disorder].

Introduction: Cognitive evoked potentials (P300) have been core of interest in attention deficit hyperactivity disorder (ADHD) research. The identification of its relationship with the most ecological aspects of executive dysfunction involves a link between neurophysiological and functional frames for a better treatment approach and monitoring of the evolution of the disorder.

Aims: To explore the differences in latency and amplitude of P300 component in Cz, Fz and Pz, between ADHD and no-ADHD children, and to analyze the correlations between variables of P300 and indexes of a measurement of executive functioning at home.

Neuropsychological correlates of emotional lability in children with ADHD.

Background: Emotional lability (EL) is commonly seen in patients with attention-deficit/hyperactivity disorder (ADHD). The reasons for this association remain currently unknown. To address this question, we examined the relationship between ADHD and EL symptoms, and performance on a range of neuropsychological tasks to clarify whether EL symptoms are predicted by particular cognitive and/or motivational dysfunctions and whether these associations are mediated by the presence of ADHD symptoms.

[Pharmacological update in attention deficit hyperactivity disorder: models of intervention and new drugs].

INTRODUCTION. Attention deficit hyperactivity disorder (ADHD) is the most frequent neurodevelopmental problem in childhood, with significant repercussions that continue into adulthood. This means that an appropriate therapeutic intervention is vital to improve its prognosis.

Aetiology for the covariation between combined type ADHD and reading difficulties in a family study: the role of IQ.

Background: Twin studies using both clinical and population-based samples suggest that the frequent co-occurrence of attention deficit hyperactivity disorder (ADHD) and reading ability/disability (RD) is largely driven by shared genetic influences. While both disorders are associated with lower IQ, recent twin data suggest that the shared genetic variability between reading difficulties and ADHD inattention symptoms is largely independent from genetic influences contributing to general cognitive ability. The current study aimed to extend the previous findings that were based on rating scale measures in a population sample by examining the generalisability of the findings to a clinical population, and by measuring reading difficulties both with a rating scale and with an objective task.

Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder.

Attention deficit hyperactivity disorder (ADHD) is a common, heritable neuropsychiatric disorder of unknown etiology. We performed a whole-genome copy number variation (CNV) study on 1,013 cases with ADHD and 4,105 healthy children of European ancestry using 550,000 SNPs. We evaluated statistically significant findings in multiple independent cohorts, with a total of 2,493 cases with ADHD and 9,222 controls of European ancestry, using matched platforms.