Publications by authors named "Fernando Martin Del Valle"
Article Synopsis
- GRIN-related disorders are rare developmental conditions in children caused by genetic variants, which often lead to various cognitive and behavioral challenges with few treatment options available.
- A non-randomized phase 2A trial tested L-serine as a potential treatment for these disorders in children aged 2-18, measuring its safety and efficacy over a 52-week period using several behavioral and cognitive assessment tools.
- Twenty-four participants were included in the study, showing improvements in specific skill areas, particularly in children with milder impairments, demonstrating promise for L-serine as a therapeutic option for those with GRIN genetic variants.
Enteroviruses (EVs) and human parechoviruses (HPeVs) are a major cause of central nervous system (CNS) infection in young infants. They have been implicated in neurodevelopmental delay, however limited data are available. The aim of this study is to describe the clinical outcome of young infants and to assess and compare the medium-term neurodevelopment following CNS infections caused by EV and HPeV.
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- Human parechoviruses (HPeV) can cause serious health issues in infants, including fever, sepsis-like symptoms, and encephalitis, and this study aimed to evaluate medium-term outcomes for infants infected without encephalitis.
- The study involved assessing 16 patients at least one year post-infection using the Ages and Stages Questionnaire-3, with follow-up evaluations to track motor function.
- Results indicated a generally positive medium-term prognosis, as most patients showed improvement in motor skills, with only one case continuing to experience gross motor dysfunction.
Article Synopsis
- - Human parechovirus (HPeV) is a recently identified virus linked to serious conditions like fever of unknown origin and meningitis in young infants; this study aimed to explore its epidemiology and clinical features.
- - Over three years, a study in 12 hospitals in Spain found that 5.52% of 850 specimens tested positive for HPeV, predominantly HPeV-3, with most cases occurring in neonates, highlighting symptoms such as fever, irritability, and gastrointestinal issues.
- - The study concluded that HPeV infections primarily occur in the spring and summer months, with a significant number of infants experiencing severe symptoms; it suggested that enhanced molecular diagnostic methods could improve patient care.
Introduction: Sleep disorders are common in children with neurological disorders. The aim of this study is to know the opinion of neuropediatricians and the prevalence of these disturbances in Spain.
Patients And Methods: Multicenter cross-sectional study (12 Spanish hospitals, 15 researchers).