Genotoxicity and pharmacokinetic characterization of ethanolic extract in rats.

The effect of ethanolic extract in rats was analyzed using genotoxicity assays and liver and gene expression. The lyophilized extract of cladodes was analyzed with LC-MS/MS. Male Wistar rats (=36) were equally distributed into six groups that did (+) or did not (-) receive cyclophosphamide treatments: Control (-); Control (+); EXP 1 (-), and EXP 1 (+), both treated with 210 mg/kg of ethanolic extract; and EXP 2 (-) and EXP 2 (+), both treated with 420 mg/kg of ethanolic extract.