Publications by authors named "Fernando M Alonso"
Genomic data reveals the emergence of the co-occurrence of bla and bla in an Escherichia coli ST648 strain isolated from rectal swab within the framework of hospital surveillance.
María Piekar Verónica E Álvarez Camila Knecht Carolina Leguina Natalia García Allende Fernando M Alonso
J Glob Antimicrob Resist
March 2023
Article Synopsis
- This study investigates a multidrug-resistant strain of E. coli that produces Klebsiella pneumoniae carbapenemase (KPC), which poses a serious public health threat due to its genetic features and resistance.
- Whole-genome sequencing and various bioinformatics tools were utilized to analyze the strain's resistance genes, plasmids, and virulence factors, leading to the identification of sequence type ST648 as previously unreported for this context in Latin America.
- The findings emphasize the need for ongoing molecular surveillance to track the spread of this high-risk clone and its associated antibiotic resistance, highlighting the potential for greater global dissemination.
Objectives: Enterobacter cloacae complex (ECC) has awakened interest recently because of its increasing resistance to carbapenems codified by several genes all over the globe. Even though there are some sequence types (STs) which represent high-risk clones, there is substantial clonal diversity in the ECC. This work aimed to perform whole-genome sequencing (WGS), genomic analysis, and phylogenetic studies of a Klebsiella pneumoniae carbapenemase (KPC) -producing multidrug-resistant (MDR) ECC isolate from Argentina.
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