Complex Synaptic and Intrinsic Interactions Disrupt Input/Output Functions in the Hippocampus of Knock-Out Mice.

Pathogenic variants in have been linked to severe developmental epileptic encephalopathies including Dravet syndrome. knock-out (KO) mice model loss-of-function (LOF) disorders, demonstrating seizures, developmental delays, and early death. encodes the protein β1, an ion channel auxiliary subunit that also has roles in cell adhesion, neurite outgrowth, and gene expression.

Complex synaptic and intrinsic interactions disrupt input/output functions in the hippocampus of knockout mice.

Unlabelled: Mutations in the gene have been linked to severe developmental epileptic encephalopathies including Dravet syndrome. k nock o ut (KO) mice model loss of function disorders, demonstrating seizures, developmental delays, and early death. encodes the protein β1, an ion channel auxiliary subunit that also has roles in cell adhesion, neurite outgrowth, and gene expression.