Safety and efficacy of the combination of T-DM1 with radiotherapy of the central nervous system in a patient with HER2-positive metastatic breast cancer: case study and review of the literature.

Approximately 35% of patients with confirmed HER2 breast cancer progress to metastases of the central nervous system (CNS). Total cerebral radiotherapy is considered as standard treatment for these cases; however, studies have shown that some chemotherapy drugs can be used during radiotherapy without significantly increasing its toxicity. In this article, we report the case of a patient with HER2-positive breast cancer who showed isolated progression of the illness in the CNS, which was observed during the treatment period using T-DM1 concomitantly with radiotherapy of the CNS without apparent toxicity of the combination and keeping the illness controlled.

Recurrent wheezing in infants: epidemiological changes.

Objective: To determine epidemiological changes in recurrent wheezing among infants in Curitiba, Brazil.

Methods: This cross-sectional study used the questionnaire Estudio Internacional de Sibilancias en Lactantes (EISL). Parents of infants aged 12 to 15 months completed the instrument from August 2005 to December 2006 (phase I) and from September 2009 to September 2010 (phase III).