Publications by authors named "Fernando Diaz-Otero"

Article Synopsis
  • Cardioembolic stroke poses a significant risk for patients with nonischemic dilated cardiomyopathy (NIDCM), but anticoagulation therapy is complicated by bleeding risks.* -
  • A study involving patients with NIDCM showed that stasis metrics obtained from echocardiography correlate with the risk of stroke and could help identify those who benefit most from prevention strategies.* -
  • The findings indicate that using echocardiographic indices of blood flow stasis in patients without atrial fibrillation may effectively predict and manage stroke risks in NIDCM.*
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Introduction And Objectives: In the setting of ST-segment elevation myocardial infarction (STEMI), imaging-based biomarkers could be useful for guiding oral anticoagulation to prevent cardioembolism. Our objective was to test the efficacy of intraventricular blood stasis imaging for predicting a composite primary endpoint of cardioembolic risk during the first 6 months after STEMI.

Methods: We designed a prospective clinical study, Imaging Silent Brain Infarct in Acute Myocardial Infarction (ISBITAMI), including patients with a first STEMI, an ejection fraction ≤ 45% and without atrial fibrillation to assess the performance of stasis metrics to predict cardioembolism.

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Flow cytometry (FC) is widely used in microbiology, immunology, hematology, and oncology. In the veterinary field, FC enabled the study of the immune response in cattle infected with different pathogens, as well as vaccine testing. However, few fluorochrome-conjugated antibodies recognize bovine antigens, limiting the possible benefits of FC and the implementation of multiparametric analysis for more complex studies.

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Background And Objectives: COVID-19-related inflammation, endothelial dysfunction, and coagulopathy may increase the bleeding risk and lower the efficacy of revascularization treatments in patients with acute ischemic stroke (AIS). We aimed to evaluate the safety and outcomes of revascularization treatments in patients with AIS and COVID-19.

Methods: This was a retrospective multicenter cohort study of consecutive patients with AIS receiving intravenous thrombolysis (IVT) and/or endovascular treatment (EVT) between March 2020 and June 2021 tested for severe acute respiratory syndrome coronavirus 2 infection.

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Background And Purpose: The experience gained during the first COVID-19 wave could have mitigated the negative impact on stroke care in the following waves. Our aims were to analyze the characteristics and outcomes of patients with stroke admitted during the second COVID-19 wave and to evaluate the differences in the stroke care provision compared with the first wave.

Methods: This retrospective multicenter cohort study included consecutive stroke patients admitted to any of the seven hospitals with stroke units (SUs) and endovascular treatment facilities in the Madrid Health Region.

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Introduction: Orolingual angioedema (OA) after intravenous thrombolysis (IVT) with alteplase in acute stroke can be a life-threatening complication. Our aim was to describe its incidence, clinical features, and related factors.

Patients And Methods: We analyzed a single-center cohort of stroke patients treated with IVT in an 8-year period.

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Introduction: We analyzed whether the coronavirus disease 2019 (COVID-19) crisis affected acute stroke care in our center during the first 2 months of lockdown in Spain.

Methods: This is a single-center, retrospective study. We collected demographic, clinical, and radiological data; time course; and treatment of patients meeting the stroke unit admission criteria from March 14 to May 14, 2020 (COVID-19 period group).

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Objective: To describe the spectrum of neurological complications observed in a hospital-based cohort of COVID-19 patients who required a neurological assessment.

Methods: We conducted an observational, monocentric, prospective study of patients with a COVID-19 diagnosis hospitalized during the 3-month period of the first wave of the COVID-19 pandemic in a tertiary hospital in Madrid (Spain). We describe the neurological diagnoses that arose after the onset of COVID-19 symptoms.

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Article Synopsis
  • * A study conducted at 7 stroke centers during the early pandemic revealed that while there was a significant drop in stroke admissions, the management of confirmed and suspected COVID-19 patients showed no differences in reperfusion therapy but had longer treatment times.
  • * Patients with confirmed or suspected COVID-19 experienced worse outcomes compared to non-COVID-19 stroke patients, highlighting the severity of strokes in those infected and emphasizing the importance of a robust stroke care network to lessen pandemic impacts.
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Article Synopsis
  • Recent studies suggest a link between COVID-19 and severe acute ischemic strokes, highlighting the need for further research to confirm this association and inform treatment strategies for stroke patients.
  • A cohort of 174 COVID-19 patients with acute ischemic stroke was analyzed, revealing that those with COVID-19 generally had more severe strokes compared to non-COVID-19 patients.
  • In a matched sample of 336 patients, those with COVID-19 were found to have a higher risk of severe disability and a notable death rate, indicating worse outcomes associated with COVID-19-related strokes.
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Background: Cardioembolic stroke is a major source of mortality and disability worldwide. The authors hypothesized that quantitative characterization of intracardiac blood stasis may be useful to determine cardioembolic risk in order to personalize anticoagulation therapy. The aim of this study was to assess the relationship between image-based metrics of blood stasis in the left ventricle and brain microembolism, a surrogate marker of cardiac embolism, in a controlled animal experimental model of acute myocardial infarction (AMI).

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Background: Transient focal neurological episodes (TFNEs) are a recently recognized clinical presentation of cerebral amyloid angiopathy (CAA). Our aim was to describe the clinical and radiological features of a series of patients with AS.

Methods: We included 11 patients presenting with recurrent transient focal neurological symptoms and radiological features related to CAA.

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Background: Time to treatment remains the most important factor in acute ischemic stroke prognosis. We quantified the effect of new interventions reducing in-hospital delays in acute stroke management and assessed its repercussion on door-to-imaging (DTI), imaging-to-needle (ITN), and door-to-needle (DTN) times.

Methods: Prospective registry of consecutive stroke patients who were candidates for reperfusion therapy attended in a tertiary care hospital from February 1 to December 31, 2014.

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Article Synopsis
  • - The study analyzed outcomes and complications of mechanical thrombectomy (MT) for basilar artery occlusions (BAO) compared to anterior circulation occlusions, finding that BAO patients experienced longer procedure times and a lower recanalization rate.
  • - Patients with BAO had a higher rate of mortality (33% vs 12%) and lower independence at 3 months (40% vs 58%) compared to those with anterior circulation occlusions, along with a trend of more procedural complications.
  • - The findings suggest that MT is more complex with a higher chance of futile recanalization in BAO cases, particularly influenced by older age and longer procedure durations, indicating a need for refined endovascular approaches for better outcomes. *
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Background And Purpose: The present study was conducted with the objective of evaluating the safety of primary mechanical thrombectomy (MT) in patients with large vessel occlusion (LVO) stroke and comorbidities that preclude treatment with IV thrombolysis (IVT), compared with patients who received standard IVT treatment followed by MT. Secondary objectives were to analyse the recanalization rate and outcomes.

Methods: A prospective observational multicenter study (FUN-TPA) that recruited patients treated within 4.

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La deficiencia de vitamina A es infrecuente en los países desarrollados. La cirugía bariátrica constituye un factor de riesgo de deficiencia de esta vitamina. Se han descrito varios casos en pacientes sometidos a técnicas con un importante componente malabsortivo, como la derivación biliopancreática.

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Introduction: Reliable predictors of poor clinical outcome despite successful revascularization might help select patients with acute ischemic stroke for thrombectomy. We sought to determine whether baseline Alberta Stroke Program Early CT Score (ASPECTS) applied to CT angiography source images (CTA-SI) is useful in predicting futile recanalization.

Methods: Data are from the FUN-TPA study registry (ClinicalTrials.

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Background And Purpose: The complexity of endovascular revascularization treatment (ERT) in acute ischemic stroke and the small number of patients eligible for treatment justify the development of stroke center networks with interhospital patient transfers. However, this approach might result in futile transfers (ie, the transfer of patients who ultimately do not undergo ERT). Our aim was to analyze the frequency of these futile transfers and the reasons for discarding ERT and to identify the possible associated factors.

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A dose of 0.9 mg/kg of intravenous tissue plasminogen activator (t-PA) has proven to be beneficial in the treatment of acute ischemic stroke (AIS). Dosing of t-PA based on estimated patient weight (PW) increases the likelihood of errors.

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Background: Vascular imaging is increasingly used for diagnosis of arterial occlusions in acute ischemic stroke (AIS) patients. Our aim was to determine whether computed tomography angiography (CTA) and Doppler/duplex ultrasound (DUS) before intravenous thrombolysis (IVT) is associated with a delay in time-to-treatment.

Methods: Observational analysis of a prospective cohort of AIS patients treated with IVT from January 2009 to December 2012.

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Introduction: Bilateral carotid artery occlusion (BCAO) is a rare and poorly studied entity. The medium-long term prognosis reported is variable. Collateral circulation must play a crucial role in the outcome, however, the evidence in literature is scarce.

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Prolactin receptor (PRLr) is a member of the cytokine receptor superfamily 1 showing tissue specific structural diversity. Expression of PRLr isoforms in lymphoid tissues has been associated with immunomodulatory function of prolactin. Bovine tuberculosis (bTB) is characterized by chronic inflammation caused by the persistent infection of lymphoid tissues with Mycobacterium bovis.

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