Publications by authors named "Fernando Calvo-Boyero"
Reuse of Electronic Health Records (EHRs) for specific diseases such as COVID-19 requires data to be recorded and persisted according to international standards. Since the beginning of the COVID-19 pandemic, Hospital Universitario 12 de Octubre (H12O) evolved its EHRs: it identified, modeled and standardized the concepts related to this new disease in an agile, flexible and staged way. Thus, data from more than 200,000 COVID-19 cases were extracted, transformed, and loaded into an i2b2 repository.
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- COVID-19 has highlighted the importance of electronic health records (EHRs) for timely healthcare responses and secondary uses like biomedical research, though varying data models create redundancy in data entry.
- The study aimed to create a flexible methodology using detailed clinical models (DCM) to effectively reuse EHRs from a tertiary hospital while maintaining data integrity and saving time.
- The methodology involved four stages, including identifying relevant variables for COVID-19 and designing an algorithm in R, and was successfully implemented for 4,489 patients at a large hospital.
Gene-gene interactions between DRD3, MRP4 and CYP2B6 polymorphisms and its influence on the pharmacokinetic parameters of efavirenz in HIV infected patients.
Drug Metab Pharmacokinet
October 2016
Genetic factors have a significant impact on the PK variability of EFV, much higher than other non-genetic factors, such as demography. In this work we have performed a comprehensive PG analysis of genes encoding the major metabolizing enzymes and transporters of EFV, establishing a clear relationship between the PK parameters and genetic factors, which explain 50% of the variability in EFV PK parameters. The most relevant associations for metabolizing enzymes were found in CYP2B6 (rs3745274), in agreement with previous studies.
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