Publications by authors named "Fernando Aldeia"
Article Synopsis
- - Colorectal cancer (CRC) exhibits significant genetic diversity influenced by various genomic instability pathways, resulting in differences within tumors and their surrounding environments.
- - A study of 136 CRC samples revealed that this diversity arises from molecular alterations that occur at different rates, with certain genomic features being better predictors of heterogeneity in tumor subtypes and locations.
- - The research indicates that higher levels of genetic and microenvironment diversity are linked to a reduced likelihood of metastasis, while certain genetic changes that appear later may promote the spread of cancer cells.
Colorectal cancer (CRC) is one of the most lethal malignancies. The extreme heterogeneity in survival rate is driving the need for new prognostic biomarkers. Human endogenous retroviruses (hERVs) have been suggested to influence tumor progression, oncogenesis and elicit an immune response.
View Article and Find Full Text PDFPurpose: During radiotherapy the peritumoral tissues are daily exposed to subtherapeutic doses of ionizing radiation. Herein, the biological and molecular effects of doses lower than 0.8 Gy per fraction (LDIR), previously described as angiogenesis inducers, were assessed in human peritumoral tissues.
View Article and Find Full Text PDFPurpose: During radiotherapy the peritumoral tissues are daily exposed to subtherapeutic doses of ionizing radiation. Herein, the biological and molecular effects of doses lower than 0.8 Gy per fraction (LDIR), previously described as angiogenesis inducers, were assessed in human peritumoral tissues.
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