Retrosternal goiter and chylothorax: case report.

We describe a case of chylothorax associated with a retrosternal goiter. Such an association has not been previously reported. The chylothorax was probably caused by compression of the thoracic duct and brachiocephalic vessels.

Quantitative morphological studies of aging changes in the kidney of the Lewis rat.

Spontaneous aging changes in the kidneys of the rat have been previously described. In the Lewis strain, we performed semiquantitative studies of kidney histology and quantitative studies of glomerular basement membrane thickness and mesangial area in animals aged 6-30 months. There is a progressive increase in glomerular basement membrane thickness and mesangial area throughout the life of the rat.

Papillary adenocarcinomatous degeneration occurring in a multilocular renal cyst.

A multilocular cyst of the kidney in an adult with malignant papillary adenocarcinomatous transformation is described. The histogenesis and prognosis of multilocular cysts are discussed with special reference to their relationship with Wilms' tumour.

Experimental portal hypertension in the rat.

Previous attempts to produce sustained portal hypertension in experimental animals by portal venous obstruction have not been successful. Experiments were designed to study the effects of gradual portal venous occlusion plus hepatic lymphatic ligation in the rat. Adult male Lewis rats were divided into three groups: (A) nonoperated or sham-operated; (B) operated, with hepatic lymphatic ligation only; and (C) operated, with placement of a portal vein ameroid constrictor and hepatic lymphatic ligation.

Prevention by whole pancreas transplantation of glomerular basement membrane thickening in alloxan diabetes.

Serial thickness measurements of the glomerular basement membrane were performed over a 24-month period in four groups of inbred male Lewis rats. Group I consisted of normal animals age-matched to the remaining experimental groups. In groups II, III, and IV, diabetes was induced by intravenous alloxan (42 to 44 mg/kg).