Size-Controlled Self-Assembly for Bimodal In Vivo Imaging.

Contrast agents (CAs) are essential in biomedical imaging to aid in the diagnosis and therapy monitoring of disease. However, they are typically restricted to one imaging modality and have fixed properties such as size, shape, toxicity profile, or photophysical characteristics, which hampers a comprehensive view of biological processes. Herein, rationally designed dye assemblies are introduced as a unique CA platform for simultaneous multimodal and multiscale biomedical imaging.

Risk of preeclampsia and other pregnancy complications in frozen single euploid embryo transfers after natural versus artificial endometrial preparation: A truncated randomized controlled trial.

Introduction: To determine for the first time the incidence of preeclampsia and other pregnancy complications according to the mode of endometrial preparation for frozen embryo transfer (FET) in a randomized fashion.

Methods: Women about to undergo FET of a single euploid blastocyst were randomly assigned to a modified natural cycle (MNC) or an artificial cycle (AC). Inclusion criteria were as follows: Caucasian; non-obese; 18-43 years of age; nulliparity; regular menstrual cycles; and autologous oocytes.

Long-Term Exposure to Lambda-Cyhalothrin Reveals Novel Genes Potentially Involved in Insecticide Resistance.

Insecticide resistance in populations hinders vector control programs. Many studies have focused on the classical mechanisms, mutations, and metabolic enzymes to understand the development of insecticide resistance. In this study, we subjected a strain of to selective pressure for 13 consecutive generations to understand the development and extent of insecticide resistance.

Corrigendum to "Renal Disease in Metabolic Syndrome: the Hidden Role of Intrarenal Ischemia" [ Volume 9, Issue 5, May 2024, Pages 1419-1428].

[This corrects the article DOI: 10.1016/j.ekir.

Transcriptomic analysis of benznidazole-resistant Trypanosoma cruzi clone reveals nitroreductase I-independent resistance mechanisms.

The enzyme nitroreductase I (NTRI) has been implicated as the primary gene responsible for resistance to benznidazole (Bz) and nifurtimox in Trypanosoma cruzi. However, Bz-resistant T. cruzi field isolates carrying the wild-type NTR-I enzyme suggest that additional mechanisms independent of this enzyme may contribute to the resistance phenotype.

Germline structural variant as the cause of Lynch Syndrome in a family from Ecuador.

Colorectal cancer (CRC) is one of the most common cancers worldwide. Lynch Syndrome (LS) is the most common form of hereditary CRC and it is caused by germline defects in the DNA-mismatch repair (MMR) pathway. It is of extreme importance for affected LS patients and their relatives to identify the germline causative alteration to provide intensified surveillance to those at risk and allow early diagnosis and cancer prevention.

Lactation, mastitis, and probiotics.

Exclusive breastfeeding during the first six months of life, and prolonged with complementary feeding until 2 years of age or more, is the best nutritional approach in the first stage of life. Mastitis is a pathology that can jeopardize the continuity of breastfeeding. Different methods have been proposed for the prevention and treatment of mastitis, including probiotics.

Interactions between contaminants and the trophic ecology of two seabirds in a coastal lagoon of the Gulf of California.

Monitoring the dynamics of contaminants in ecosystems helps understand their potential effects. Seabirds have been used as biomonitors of marine ecosystems for this purpose. However, exposure and vulnerability to pollutants are understudied in tropical species, and the relationships between various pollutants and the trophic ecology of seabirds are poorly understood.

HeberNasvac: Development and Application in the Context of Chronic Hepatitis B.

Unlabelled: The immune system plays a central role in controlling acute hepatitis B infection and in patients resolving chronic hepatitis B (CHB). Given that 221 million (75%) of CHB patients reside in low- and middle-income countries, the development of a vaccine with therapeutic properties represents a rational and cost-effective approach more than a romantic endeavor. This review systematically analyzes the key variables related to the safety, efficacy, and effectiveness of CHB treatments.

Mediating effects of social support between telework and well-being: protocol for a systematic review.

Introduction: Research on telework has grown dramatically in recent years, leading to a fragmented set of findings on its effect on workers' well-being. One of the most studied social mechanisms concerns how telework alters the transmission of social support between family members and coworkers, which turns out to be a mediating factor between teleworking and well-being. This research contributes to the understanding of this issue by analysing the existing evidence on the effect of telework on social support and well-being before, during and after the pandemic.

Selective Colocalization of GHSR and GLP-1R in a Subset of Hypothalamic Neurons and Their Functional Interaction.

The GH secretagogue receptor (GHSR) and the glucagon-like peptide-1 receptor (GLP-1R) are G protein-coupled receptors with critical, yet opposite, roles in regulating energy balance. Interestingly, these receptors are expressed in overlapping brain regions. However, the extent to which they target the same neurons and engage in molecular crosstalk remains unclear.

Phylogeography, taxonomy, and conservation of the endangered brown howler monkey, (Primates, Atelidae), of the Atlantic Forest.

The brown howler, , endemic to the Atlantic Forest of Brazil and Argentina, is threatened by habitat loss and fragmentation, hunting, and its susceptibility to yellow fever. Two subspecies have been recognized, but their names, validity, and geographic ranges have been controversial. We obtained samples covering the species' entire distribution in Brazil and Argentina to clarify these issues by investigating their genetic diversity and structure and assessing their evolutionary history.

Development and characterization of fluorescent cholesteryl probes with enhanced solvatochromic and pH-sensitive properties for live-cell imaging.

We present novel fluorescent cholesteryl probes (CNDs) with a modular design based on the solvatochromic 1,8-phthalimide scaffold. We have explored how different modules-linkers and head groups-affect the ability of these probes to integrate into lipid membranes and how they distribute intracellularly in mouse astrocytes and fibroblasts targeting lysosomes and lipid droplets. Each compound was assessed for its solvatochromic behavior in organic solvents and model membranes.

The relationship between brain structure and function during novel grammar learning across development.

In this study, we explored the relationship between developmental differences in gray matter structure and grammar learning ability in 159 Dutch-speaking individuals (8 to 25 yr). The data were collected as part of a recent large-scale functional MRI study (Menks WM, Ekerdt C, Lemhöfer K, Kidd E, Fernández G, McQueen JM, Janzen G. Developmental changes in brain activation during novel grammar learning in 8-25-year-olds.

Growth hormone secretagogue receptor and cannabinoid receptor type 1 intersection in the mouse brain.

The growth hormone secretagogue receptor (GHSR) and the cannabinoid receptor type 1 (CB1R) are G-protein coupled receptors highly expressed in the brain and involved in critical regulatory processes, such as energy homeostasis, appetite control, reward, and stress responses. GHSR mediates the effects of both ghrelin and liver-expressed antimicrobial peptide 2, while CB1R is targeted by cannabinoids. Strikingly, both receptors mediate their effects by acting on common brain areas and their individual roles have been well characterized.

Control of Green Mold and Sour Rot in Mandarins by Postharvest Application of Natamycin and an Allium Extract.

The efficacy of natamycin (Fruitgard Nat 20) and Proallium (an extract of allium including propyl thiosulfinate oxide (PTSO)) against sour rot and green mold in mandarins was evaluated under controlled and commercial conditions. The study involved artificial inoculation of Nova, Tango, Orri, Afourer, Murcott, and Nules Clementine mandarins with isolates of resistant to imazalil and pyrimethanil and an isolate of susceptible to propiconazole fungicides. Under laboratory conditions, natamycin applied at 1500 µg mL significantly reduced green mold by 61.

Stress enhances memory for previously encoded events depending on stressor recall.

Stressful events are typically well remembered, but their effects on memory for surrounding neutral events and the underlying mechanisms remain less clear. We hypothesized that stress would enhance memory for events surrounding the stressor, contingent on the memory of the stressor itself. Additionally, we predicted that memory for neutral events would be modulated by pairing them with stressor-related cues.

A systems biology approach unveils different gene expression control mechanisms governing the immune response genetic program in peripheral blood mononuclear cells exposed to SARS-CoV-2.

COVID-19 and other pandemic viruses continue being important for public health and the global economy. Therefore, it is essential to explore the pathogenesis of COVID-19 more deeply, particularly its association with inflammatory and antiviral processes. In this study, we used the RNA-seq technique to analyze mRNA and non-coding RNA profiles of human peripheral blood mononuclear cells (PBMCs) from healthy individuals after SARS-CoV-2 in vitro exposure, to identify pathways related to immune response and the regulatory post-transcriptional mechanisms triggered that can serve as possible complementary therapeutic targets.

Should We Offer Universal Germline Genetic Testing to All Patients with Pancreatic Cancer? A Multicenter Study.

Background: Pancreatic ductal adenocarcinoma (PDAC) is associated with a significant percentage of germline pathogenic variants (GPVs). Unlike in the United States, routine universal genetic testing is not performed in Europe. The aim of the study is to evaluate the diagnostic yield of germline genetic testing in all patients with PDAC.

OPTI-HEP-D: a protocol for an intervention study comprising screening and linkage to care of people living with hepatitis D in Catalonia.

Introduction: Hepatitis B virus (HBV) affects 296 million people globally, causing 780 000 annual deaths. It has been estimated that 12-43 million individuals are co-infected with hepatitis D virus (HDV). In Spain, the prevalence of HBsAg in adults is 0.

The Empty Office: protocol for sequential mixed-method study on the impact of telework activities on social relations and well-being.

Introduction: Teleworking is one of the most significant legacies of the pandemic. Great attention is now being paid to its effects on workers' health. One of the arguments that emerged on this issue is that 'working away from the office' affects the time we spend with significant others.