Publications by authors named "Fernandez Antonio"

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  • Two natural -kaurene diterpenoids were extracted from a plant, and six new derivatives were synthesized for evaluation of their anti-tumor properties against three types of cancer cells (colon, liver, and melanoma).
  • One synthesized compound showed the strongest anti-proliferative effects across all cell lines, with a notable IC value of around 2.5 μM, and further studies indicated that some derivatives induced a selective G2/M cell cycle arrest.
  • Apoptosis analysis revealed that certain compounds led to high levels of cell death (up to 99% apoptosis), linked to mitochondrial dysfunction and the activation of the intrinsic apoptotic pathway, suggesting their potential as effective anticancer agents.
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  • The Canary Islands feature a rich diversity of marine species, particularly in stranded cetaceans, which provide valuable scientific insights.
  • The study analyzed 233 stranded cetaceans from 2018 to 2022, identifying 18 types of parasites, with adult and juvenile animals being the most affected.
  • Accurate identification of these parasites is crucial for understanding disease patterns, evaluating the health of cetacean populations, and crafting conservation strategies.
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The European Bison (Bison bonasus) is the largest mammal in Europe and is classified as an endangered species. Leishmaniosis is a vector-borne disease caused by the protozoan Leishmania infantum. In general, this infection has been associated with dogs, cats, and humans.

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  • Persistent subcutaneous granulomas develop at the injection site after administering aluminium oxyhydroxide (AlOOH), a common vaccine adjuvant, and can facilitate the infection of macrophages by small ruminant lentiviruses (SRLVs) in sheep.
  • The study involved 24 male lambs that underwent vaccination followed by SRLV infection, revealing that the granulomas, initially large, decreased in size over time and exhibited various features including central necrosis and keratin presence.
  • The research highlighted significant differences in the expression of the mannose receptor and the restriction factor A3Z1 in relation to the vaccine type and time, suggesting that macrophage polarization might affect SRLV infection, though the overall structure of the granulomas remained
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Background: Our primary objective evaluated the perception of emergency medical service (EMS) providers' review of automated hospital outcome data. Secondarily, we assessed participation in outcome review as a means of microlearning to obtain continuing education (CE).

Methods: From October-December 2023, three high-volume EMS systems participated in a three-part intervention with results evaluated using a mixed-methods approach.

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  • Cetaceans, particularly Kogia species, play a vital role in marine ecosystems as top predators, but they face significant threats from human activities in the Macaronesian region.
  • A study of Kogia whales stranded and sighted in the Canary Islands over several decades revealed 111 stranding events and 36 sightings, highlighting the prevalence of K. breviceps and K. sima in these waters.
  • These findings provide crucial baseline data for future conservation efforts and emphasize the need for better understanding and protection of these elusive cetaceans.
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Transcranial magnetic stimulation (TMS) to early visual cortex modulates the effect of adaptation and eliminates the effect of exogenous (involuntary) attention on contrast sensitivity. Here, we investigated whether adaptation modulates exogenous attention under TMS to V1/V2. Observers performed an orientation discrimination task while attending to one of two stimuli, with or without adaptation.

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Introduction: External injuries in elasmobranchs are frequent findings, either due to inter- or intraspecific interactions or as a result of interaction with human activities. However, the resilience of these species to traumatic injury remains poorly understood. This work provides an insight into the clinical presentation, diagnostic imaging, and pathological features of a severe traumatic injury to the cartilaginous skeleton of a spiny butterfly ray ().

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is a major vector of in the Mediterranean. While the seroprevalence of leishmaniosis in Spanish dogs and cats has been studied, data on the exposure of cats to bites under natural conditions without repellents is limited. Stray cats could serve as sentinels for and exposure.

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Aims: To assess the outcomes of robotic surgery for patients with neurogenic lower urinary tract dysfunctions (NLUTD).

Materials And Methods: Studies evaluating the outcomes (efficacy and safety) of robot-assisted ileal conduit creation or artificial urinary sphincter (R-AUS) implantation or augmentation cystoplasty or continent urinary diversion creation in patients with NLUTD were included. The search strategy and studies selection were performed on Medline, Embase and Cochrane using the PICOS method according to the PRISMA statement (PROSPERO 2022 CRD42022333157).

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The prognosis of people with cystic fibrosis (pwCF) has improved dramatically with the introduction of cystic fibrosis transmembrane conductance regulator (CFTR) modulators (CFTRm). The ageing of the cystic fibrosis (CF) population is changing the disease landscape with the emergence of different needs and increasing comorbidities related to both age and long-term exposure to multiple treatments including CFTRm. Although the number of pwCF eligible for this treatment is expected to increase, major disparities in care and outcomes still exist in this population.

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Ovine anaplasmosis is causing relevant economic losses in Spain due to icteric carcass condemnation in lambs. Anaplasma ovis infection occurs through grazing sheep that transfer ticks to their offspring. This study compared the efficacy of deltamethrin and cypermethrin pour-on treatments for tick control.

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Paratuberculosis (PTB), caused by subspecies (MAP), is a chronic disease with economic impact on ruminant farming worldwide. The Canary Islands count with the fourth largest goat population in Spain and are "officially free" of bovine tuberculosis. Twelve farms were included with 2774 serum samples tested by an enzyme-linked immunosorbent assay (ELISA) for detection of anti-MAP antibodies in two sessions.

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Article Synopsis
  • A study examined mesenteric lymph nodes and ileocecal valves from 105 goats (61 non-vaccinated, 44 vaccinated) with a history of paratuberculosis (PTB) to assess the presence of subclinical infections and lesions.
  • Results revealed that 39% of the goats had gross PTB-compatible lesions, with a higher prevalence in non-vaccinated goats compared to vaccinated ones.
  • The research highlighted the importance of using both histopathological assessments and laboratory techniques to accurately diagnose PTB, but calls for further research to improve sampling methods for subclinical cases in goats.
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Glioblastoma (GB) is the most common and fatal type of primary malignant brain tumor for which effective therapeutics are still lacking. GB stem cells, with tumor-initiating and self-renewal capacity, are mostly responsible for GB malignancy, representing a crucial target for therapies. The TP73 gene, which is highly expressed in GB, gives rise to the TAp73 isoform, a pleiotropic protein that regulates neural stem cell biology; however, its role in cancer has been highly controversial.

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Endothelial function declines with aging and independently predicts future cardiovascular disease (CVD) events. Diving also impairs endothelial function in humans. Yet, dolphins, being long-lived mammals adapted to diving, undergo repetitive cycles of tissue hypoxia-reoxygenation and disturbed shear stress without manifesting any apparent detrimental effects, as CVD is essentially nonexistent in these animals.

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  • Bird collisions with overhead lines, like power and phone lines, are contributing to the decline of various bird species, particularly the endangered Canarian houbara bustard.
  • A necropsy study of nine houbara bustards that collided with these lines showed that trauma was the cause of death for all, with common severe injuries including fractures and hemorrhages.
  • The study found that many birds endure the initial impact and may survive for a short period (minutes to hours) before succumbing to their injuries, suggesting that post-trauma analysis techniques could help determine the timeline from injury to death.
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Purpose: Acute stroke is a serious, time-sensitive condition requiring immediate medical attention. Emergency medical services (EMS) routing and direct transport of acute stroke patients to stroke centers improves timely access to care. This study aimed to describe EMS stroke routing and transports by rurality in North Carolina (NC).

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Background And Hypothesis: Assess incidence of Acute Kidney Diseas and Disorders (AKD) and Acute Kidney Injury (AKI) episodes and impact on progression of renal dysfunction and risk of all-cause mortality in the community.

Methods: Community of 1 863 731 aged > 23 years with at least two serum creatinine measurements. eGFR was calculated using CKD-EPI formula.

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Background: Firefighters have a high prevalence of cardiovascular disease. The poor heart health of firefighters is implicated in their increased risk of sudden cardiac death (SCD). Exercise may be protective against SCD partially due to the immediate blood pressure (BP) reductions of 5-8 mmHg following exercise, termed postexercise hypotension (PEH) OBJECTIVES: To examine PEH under ambulatory conditions after a maximal cardiopulmonary exercise test (CPET) among career firefighters METHODS: Firefighters (n = 19) completed a maximal CPET and non-exercise control (CONTROL) in random order on separate non-workdays and left the laboratory instrumented to an ambulatory BP (ABP) monitor.

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  • Pseudomonas luteola is a gram-negative bacterium that thrives in humid environments and can cause infections mainly in immunocompromised individuals, often after invasive medical procedures.
  • The bacterium was first reported as a pathogen in ferrets in Spain in 2012 and has since been identified sporadically in various countries, associated with serious conditions like respiratory disease and abscesses.
  • A clinical case demonstrated successful non-invasive treatment for a ferret with ulcerative pododermatitis and lymphadenitis caused by P. luteola, highlighting the importance of early detection and intervention.
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), considered a zoonotic agent of wildlife origin, can infect various animal species, including wildlife in free-range and captive environments. Detecting susceptible species and potential reservoirs is crucial for preventing the transmission, spread, genetic evolution, and further emergence of viral variants that are major threats to global health. This study aimed to detect exposure or acute infection by SARS-CoV-2 in 420 animals from 40 different wildlife species, including terrestrial and aquatic mammals, from different regions of Spain during the 2020-2023 coronavirus disease 19 (COVID-19) pandemic.

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In Europe, is the most prevalent species, and this protozoan is transmitted by phlebotomine sandflies. A recent publication has shown that sheep harbor antibodies. This raises questions about the epidemiological role of small ruminants.

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Hydrogen-bonded organic frameworks (HOFs) are a new class of crystalline porous organic molecular materials (POMMs) with great potential for a diverse range of applications. HOFs face common challenges to POMMs, and in general to purely organic crystals, that is, the difficulty of integrating complexity in crystals. Herein, we propose a simple and sequential strategy for the formation of HOFs with hierarchical superstructures.

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