Bioactive silicon-based dental gel associated with a calcium booster for dentin hypersensitivity treatment: A randomized clinical study.

Background: Dentin hypersensitivity affects a significant portion of the world's population, causing pain and negatively impacting oral health and quality of life This clinical study investigated the effectiveness of a desensitizing fluoride silicon-rich dental gel associated with a calcium booster.

Material And Methods: In this single-blind, randomized, parallel-group clinical trial, forty-eight volunteers diagnosed with dentin hypersensitivity and qualified to participate were randomized into 2 groups: (1) fluoride silicon-rich dental gel (REFX Technology)/calcium booster (Si/Ca protocol); (2) Pumice stone diluted in saline. A draw was carried out between the right and left sides of the patients so that either a prophylaxis with the dental gel associated with calcium or with fine pumice stone diluted in saline was carried out.

Immune responses of cattle vaccinated by various routes with Mycobacterium bovis Bacillus Calmette-Guérin (BCG).

Background: Mycobacterium bovis BCG is the human tuberculosis vaccine and is the oldest vaccine still in use today with over 4 billion people vaccinated since 1921. The BCG vaccine has also been investigated experimentally in cattle and wildlife by various routes including oral and parenteral. Thus far, oral vaccination studies of cattle have involved liquid BCG or liquid BCG incorporated into a lipid matrix.

Multidisciplinary nursing care in chronic Chagas disease: a scoping review.

Background: Nurses provide essential care for symptomatic chronic Chagas disease carriers, caused by Trypanosoma cruzi, offering crucial support, symptom management, medication administration, and monitoring to enhance their health-related quality of life.

Objective: To increase healthcare professionals' awareness of the critical role played by high-quality care in the management of patients with chronic Chagas disease.

Methods: This scoping review employed the PRISMA-ScR method as a framework for article selection.

Environmental triggers and ecological implications of a harmful algal bloom in the northern Arabian/Persian Gulf: Insights into the driving forces and consequences.

The Arabian/Persian Gulf, a marginal sea of the northern Indian Ocean, has been significantly impacted by human activities, leading to a rise in harmful algal blooms (HABs). This study investigates the summer blooming of an ichthyotoxic phytoflagellate Chattonella marina var. antiqua and associated fish-kill in Kuwaiti waters, connecting the events to a previous dust storm and eutrophication status in the coastal waters of the Northern Arabian Gulf (NAG).

sp. nov, . sp. nov, . sp. nov, . sp. nov and . sp. nov: five new species isolated from water sources in the Midwestern United States.

Isolates of spp. were cultured from water sources at five different sites in central Iowa in the Midwestern United States and characterized by whole-genome sequencing. Isolates were helix-shaped and motile.

Soothing the Itch: The Role of Medicinal Plants in Alleviating Pruritus in Palliative Care.

Chronic pruritus, or persistent itching, is a debilitating condition that severely impacts quality of life, especially in palliative care settings. Traditional treatments often fail to provide adequate relief or are associated with significant side effects, prompting interest in alternative therapies. This review investigates the antipruritic potential of eight medicinal plants: chamomile (), aloe vera (), calendula (), curcumin (), lavender (), licorice (), peppermint (), and evening primrose ().

Investigations into the growth and formation of biofilm by at temperatures encountered during infection.

The genus comprises unique atypical spirochete bacteria that includes the etiological agent of leptospirosis, a globally important zoonosis. Biofilms are microecosystems composed of microorganisms embedded in a self-produced matrix that offers protection against hostile factors. Leptospires form biofilms in rice fields and unsanitary urban areas, and while colonizing rodent kidneys.

New insights into the putative role of leucine-rich repeat proteins of and their participation in host cell invasion: an analysis.

Pathogenic are spirochetes that cause leptospirosis, a worldwide zoonotic disease. Leptospirosis affects humans and animals, with approximately 1 million human infections and 60,000 deaths per year. The diversity of leptospiral strains and serovars allied to the fact that pathogenesis is not yet fully understood, make the development of an effective vaccine against leptospirosis a challenge.

Analyzing temporal patterns in frequent emergency department visits among oncology patients using semantic similarity measures.

Purpose: Patients with cancer face complex challenges that often lead them to seek care in emergency departments (EDs) for acute symptoms and complications. While previous studies have examined preventable ED visits by patients with cancer, less attention has focused on frequent ED use in this population. This study aimed to explore the temporal visit patterns of frequent ED users with cancer.

Leucine-rich repeat proteins of that interact to host glycosaminoglycans and integrins.

Pathogenic spirochaetes of the genus are the etiological agents of leptospirosis, a zoonotic infection worldwide. The disease is considered an emerging and re-emerging threat due to global warming, followed by heavy rainfall and flooding when outbreaks of leptospirosis occur. Adhesion to host tissues is mediated by surface/extracellular proteins expressed by pathogens during infection.

Physical-mechanical, chemical and biological properties of graphene-reinforced glass ionomer cements.

Objectives: This study aimed to evaluate the physical-mechanical, chemical, and biological properties of graphene-reinforced glass ionomer cements (GICs).

Materials And Methods: Different proportions of graphene powder were incorporated into 2 high-viscosity self-curing GIC, Ketac Molar (G) and Fuji IX (G), in 4 different concentrations: 0.5%, 1%, 2%, and 5%.

High-intensity ethanol binge drinking accentuates bone damage in induced apical periodontitis in rats.

This study aimed to evaluate the effects of excessive and episodic consumption of ethanol (EtOH, a high-intensity drinking manner) on induced apical periodontitis in rats. Thirty-two animals were divided into the following four groups: control, EtOH, apical periodontitis, and EtOH + apical periodontitis. Ethanol exposure (3 g/kg 20 % w/v EtOH) was performed by orogastric gavage for 3 consecutive days, followed by 4 days of withdrawal for 4 weeks.

Women with low back pain do not show a pattern in the lumbopelvic muscle activation sequence that differentiates from women without low back pain.

Background: One of the causes of low back pain can be directly related to mechanical stability. Stability is the result of coordinated muscle patterns. One of the clinical tests used to assess the pattern of muscle activation is the hip extension test in the prone position, which is considered a reliable test to evaluate lumbopelvic stability.

Seasonal nutrient loadings in four monsoonal micro/meso tidal tropical estuaries, west coast of India.

Nutrient concentrations were studied seasonally along estuarine and fluvial regions of four micro/meso tidal rivers from Karnataka and Maharashtra, west coast of India. This study was performed to assess the pathway of nutrients across the salinity gradients and evaluate the impacts of weathering and human activity on nutrient concentrations. The rivers of Maharashtra had phosphate concentrations several orders of magnitude higher than the rivers of Karnataka.

Sunflower Trypsin Monocyclic Inhibitor Selected for the Main Protease of SARS-CoV-2 by Phage Display.

Main protease (Mpro), also known as 3-chymotrypsin-like protease (3CLpro), is a nonstructural protein (NSP5) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for the cleavage of virus polyproteins during viral replication at 11 sites, which generates 12 functional proteins. Mpro is a cysteine protease that presents specificity for the amino acid residue glutamine (Gln) at the P1 position of the substrate. Due to its essential role in processing the viral polyprotein for viral particle formation (assembly), Mpro inhibition has become an important tool to control coronavirus disease 2019 (COVID-19), since Mpro inhibitors act as antivirals.

Post-Metastasis Survival of Patients with High-Risk Localized and Locally Advanced Prostate Cancer Undergoing Primary Treatment in the United States: A Retrospective Study.

Background: Patients with high-risk localized and locally advanced prostate cancer (HR-LPC/LAPC) have increased risk of metastasis, leading to reduced survival rates. Segmenting the disease course [time to recurrence, recurrence to metastasis, and post-metastasis survival (PMS)] may identify disease states for which the greatest impacts can be made to ultimately improve survival.

Objective: Evaluate real-world PMS of patients with HR-LPC/LAPC who received primary radical prostatectomy (RP) or radiotherapy (RT) with or without androgen deprivation therapy (ADT).

Corpus callosum granuloma after endovascular squid embolisation of a ruptured arteriovenous malformation.

A late adolescent patient was admitted after a collapse and was found to have an intracranial haemorrhage due to an underlying midline arteriovenous malformation (AVM). The patient underwent trans-arterial squid embolisation of the AVM with good radiological resolution. 18 months later, the patient presented with new onset headaches.

Home care service for children/adolescents with special health care needs: family perception.

Objective: To apprehend the family's perception of the care provided by home care services to children and adolescents with special health needs.

Method: Qualitative, exploratory-descriptive study, carried out with 15 family members of children and adolescents with special health needs served by Home Care Services in seven municipalities in Paraíba, in 2021, selected from nine municipalities identified by previous studies. Data were collected using semi-structured interviews carried out remotely through telephone calls.

Biofilm matrix regulation by Zap1 under acidic conditions: transcriptomic and proteomic analyses.

The vaginal acidic environment potentiates the formation of biofilms, leading to complicated and recurrent infections. Importantly, the production of matrix is known to contribute to the recalcitrant features of biofilms. In this study, we reveal that Zap1 regulates the matrix of acidic biofilms and analyzed the modulation of their transcriptome (by microarrays) and matrix proteome (by LC-MS/MS) by Zap1.

Insights into young-onset dementia hospitalizations: An 8-year nationwide study using administrative data.

Objective: To characterize all Portuguese public hospitalizations of patients aged < 65 years with a primary or secondary diagnosis of dementia, based on ICD-9-CM coding.

Methods: A retrospective observational study was conducted using a nationwide database encompassing all hospitalizations occurred in Portuguese mainland public hospitals with discharge from 2008 to 2015. Hospitalizations of patients aged 35-64 years with primary or secondary diagnoses of dementia were selected based on ICD-9-CM codes 290.

Interventions for improving adherence to psychological treatments for common mental disorders: a systematic review.

Our systematic review aims to synthesise the evidence on interventions targeting improvement in patient adherence to psychological treatments for common mental disorders. A search was conducted on six electronic databases using search terms under the following concepts: common mental disorders, adherence, psychological treatments and controlled trial study design. Due to the heterogeneity in intervention content and outcomes evaluated in the included studies, a narrative synthesis was conducted.