A multi-analyses approach of inductive/deductive asymmetry in the affective priming paradigm.

Rapidly evaluating our environment's beneficial and detrimental features is critical for our successful functioning. A classic paradigm used to investigate such fast and automatic evaluations is the affective priming (AP) paradigm, where participants classify valenced target stimuli (e.g.

Generalised exponential-Gaussian distribution: a method for neural reaction time analysis.

Reaction times (RTs) are an essential metric used for understanding the link between brain and behaviour. As research is reaffirming the tight coupling between neuronal and behavioural RTs, thorough statistical modelling of RT data is thus essential to enrich current theories and motivate novel findings. A statistical distribution is proposed herein that is able to model the complete RT's distribution, including location, scale and shape: the generalised-exponential-Gaussian (GEG) distribution.

Reference values for the cross-sectional area of the lumbar multifidus muscle in children.

Background: The multifidus muscle plays a major role in the growth and postural control of children. Therefore, the reference values of the cross-sectional area (CSA) of the lumbar multifidus muscle represent an important tool for assessing muscle development and the early monitoring of musculoskeletal disorders.

Objective: The aim of this study was to provide percentile scores for the CSA of the lumbar multifidus muscle in eutrophic children aged 5 to 10 years.

Disclosing contrasting scenarios for future land cover in Brazil: Results from a high-resolution spatiotemporal model.

Gaining information on the dynamics of land cover changes is a valuable step towards improving practical conservation actions. In recent years, the Brazilian presidential elections in 2018 and the recovery from one of the nation's worst economic recessions defined a political scenario that has been causing shifts in the patterns of land cover change. A variety of national plans for the near-future exist and include the construction of new roads connecting remote Amazonian areas and large dams that could flood up to 10 million hectares.

Nanocarriers Provide Sustained Antifungal Activity for Amphotericin B and Miltefosine in the Topical Treatment of Murine Vaginal Candidiasis.

Topical drug administration is frequently used for the treatment of vaginal candidiasis; however, most formulations using this route do not provide prolonged drug release. Our aim was to evaluate the antifungal efficacy of amphotericin B (AMB) and miltefosine (MFS) incorporated in nanocarriers for sustained drug release, in a murine model of vaginal candidiasis. AMB and MFS were incorporated in different topical formulations, namely: conventional vaginal cream (daily dose for 6 days; MFS-CR and AMB-CR groups), microemulsion that transforms into a liquid crystalline gel (single dose, or in three doses, every 48 h; AMB-ME and MFS-ME groups) and alginate nanoparticles (single dose; MFS-AN group).

Alginate nanoparticles as non-toxic delivery system for miltefosine in the treatment of candidiasis and cryptococcosis.

Introduction And Objective: Previous studies indicate that miltefosine (MFS) may be an alternative as an antifungal agent; however, it presents several adverse effects. Thus, the aim of this study was to produce miltefosine-loaded alginate nanoparticles (MFS.Alg) for toxicity reduction to be used as an alternative for the treatment of cryptococcosis and candidiasis.