Publications by authors named "Fernanda Orpinelli do Rego"
Article Synopsis
- Breast cancer is the top cause of cancer-related deaths among women globally, yet there's a lack of research on metastatic breast cancer (MBC) in low- and middle-income countries, particularly regarding the genomic features of Brazilian patients.
- This study analyzed tumor samples from 328 Brazilian women with estrogen receptor-positive (ER+)/HER2-negative MBC to assess mutations in the PI3K-AKT pathway and other key genetic drivers using advanced sequencing techniques from 2020 to 2023.
- Findings indicated a 39.3% mutation prevalence in the PI3K-AKT pathway, with older patients (over 50) showing increased mutation rates and 6.1% of samples harboring mutations in the PTEN gene, especially in
