Publications by authors named "Fernanda Marques Pestana"
Article Synopsis
- - Traumatic spinal cord injury (SCI) leads to significant motor and sensory problems, and physical rehabilitation is the primary treatment currently available.
- - The study tested different exercise volumes and timing to see their effects on recovery using a mouse model after SCI, comparing groups with varying degrees of treadmill training.
- - Results showed that mice engaging in both two-phase treadmill training and subsequent extended training (TMT3) had the best outcomes for neuroregeneration, recovery, and muscle development, highlighting the importance of exercise timing and intensity after an injury.
Despite advances in technology and rehabilitation, no effective therapies are available for patients with SCI, which remains a major medical challenge. This study compared the efficacy of 3 different doses of mesenchymal stem cells (MSCs) administered by intraperitoneal injection as a therapeutic strategy for compressive SCI. We used adult female C57BL/6 mice that underwent laminectomy at the T9 level, followed by spinal-cord compression for 1 min with a 30-g vascular clip.
View Article and Find Full Text PDFPoly(lactic acid) (PLA)-containing nerve guidance conduits (NGCs) are currently being investigated for nerve repair as an alternative to autograft, which leads to permanent functional impairment in the territory innervated by the removed nerve. Combination of polymers modifies the physical properties of the conduits, altering their nerve-guidance properties. Conduits made from PLA-only or combined with other polymers have been used successfully for nerve repair, but their efficiency has not been compared.
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