Publications by authors named "Fernanda Maria Veanholi Vechiato"
Nitric oxide acutely modulates hypothalamic and neurohypophyseal carbon monoxide and hydrogen sulphide production to control vasopressin, oxytocin and atrial natriuretic peptide release in rats.
Ricardo Coletti Juliana Bezerra Medeiros de Lima Fernanda Maria Veanholi Vechiato Fabiana Lucio de Oliveira Lucas Kniess Debarba
J Neuroendocrinol
February 2019
Article Synopsis
- Nitric oxide (NO) inhibits the secretion of vasopressin (AVP), oxytocin (OT), and atrial natriuretic peptide (ANP) when extracellular osmolality rises, while carbon monoxide (CO) and hydrogen sulfide (H₂S) enhance this secretion.
- The study used an ex vivo model from male rats to test how these gases interact under hypertonic conditions, specifically looking at various chemical donors and inhibitors.
- Results showed that while NO negatively regulates hormonal release and affects other gas production in the hypothalamus, CO and H₂S primarily act to boost the secretion of these hormones, highlighting NO's critical role in the neuroendocrine response to osmotic changes
Leptin and LPS has been implicated in the development of hypothalamic astrogliosis in rodents. Astrocytes, which are interconnected by gap junction proteins, have emerged as important players in the control of energy homeostasis exerted by the hypothalamus. To investigate the hypothesis of action of T-cell protein tyrosine phosphatase (TCPTP) on the astrocyte morphology, astrocytes from the hypothalamus of one-day-old rats were stimulated with leptin and LPS (used as a positive control).
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