Influence of LGALS3 and PNPLA3 genes in non-alcoholic steatohepatitis (NASH) in patients undergone bariatric surgery.

Aim: This study evaluated the genesPNPLA3 and LGALS3 in patients who have undergone bariatric surgery.

Methods: Individuals with NAFLD and NASH were evaluated, the DNA was extracted from total blood for genotyping of rs4644, rs4652 from LGALS3 and rs738409 from PNPLA3 genes, the total RNA was obtained from liver biopsy. For the detection of the molecular targets, real-time PCR through Taqman probes was used.

Angiografic and pressoric changes determined by splenectomy with left gastric vein ligature in mansoni schistosomiasis.

Background: In hepatosplenic schistosomiasis occurs diffuse hepatic fibrosis associated with venous congestion of the portal system resulting in hepatosplenomegaly. It can produce digestive hemorrhage caused by rupture of esophageal and stomach varices or peptic gastroduodenal mucosal lesions.

Aim: To study the effects of splenectomy and ligature of the left gastric vein on portohepatic hemodynamics.