Publications by authors named "Fernanda Luiza Menezes Bello"
Article Synopsis
- Increased carbohydrate intake can lead to heart issues in mice, causing problems like cardiac hypertrophy (enlargement) and inflammation due to the activation of the NLRP3 inflammasome.
- In this study, researchers tested whether a non-hypoglycemic dose of glibenclamide could reverse heart damage caused by a high-carbohydrate (HC) diet by inhibiting the NLRP3 inflammasome.
- The results showed that glibenclamide improved heart structure and function in mice on the HC diet, reducing inflammation and oxidative stress without affecting insulin resistance.
Aims: The consumption of highly refined carbohydrates increases systemic inflammatory markers, but its potential to exert direct myocardial inflammation is uncertain. Herein, we addressed the impact of a high-refined carbohydrate (HC) diet on mice heart and local inflammation over time.
Main Methods: BALB/c mice were fed with a standard chow (control) or an isocaloric HC diet for 2, 4, or 8 weeks (HC groups), in which the morphometry of heart sections and contractile analyses by invasive catheterization and Langendorff-perfused hearts were assessed.
SummaryPrevious studies have established a model of atresia in preovulatory follicles after stimulation of immature rats with equine chorionic gonadotropin (eCG). This gonadotropin recruits a follicular pool and the deprivation of preovulatory luteinizing hormone (LH) surge induces the atresia in preovulatory follicles. The present study investigated the occurrence of ovulation and provided some morphological features of granulosa cell (GC) apoptosis of atretic follicles at 0, 48, 72 and 120 h after eCG stimulation.
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