Direct Analysis of Amphetamine Stimulants in a Whole Urine Sample by Atmospheric Solids Analysis Probe Tandem Mass Spectrometry.

Amphetamine-type stimulants (ATS) are among illicit stimulant drugs that are most often used worldwide. A major challenge is to develop a fast and efficient methodology involving minimal sample preparation to analyze ATS in biological fluids. In this study, a urine pool solution containing amphetamine, methamphetamine, ephedrine, sibutramine, and fenfluramine at concentrations ranging from 0.

Microextraction in packed sorbent for the determination of pesticides in honey samples by gas chromatography coupled to mass spectrometry.

The present work describes the development and analytical validation of a method involving microextraction packed sorbent and gas chromatography coupled to mass spectrometry (MEPS-GC-MS) for the multi-residue analysis of 22 pesticides (permethrin, fenpropathrin, aldrin, α-hexachlorocyclohexane, β-hexachlorocyclohexane, lindane, vinclozolin, endosulfan, heptaclor, dodecaclor, tetradifon, 1,1-dichloro-2,2-bis (p-chlorophenyl)ethane, 1,1-bis(p-chlorophenyl)-2,2-dichloroethylen, carbofuran, carbaryl, pirimiphos methyl, chlorpyriphos, dimethoate, disulfoton, fenamiphos, terbufos and profenofos) in honey samples. The MEPS variables of sample pH, draw-eject cycles, ionic strength and desorption procedure were optimized to improve the sensitivity of the proposed method. The method was shown to be linear at concentrations ranging from 2, 5 and 10 ng/g (limit of quantification) to 75-100 ng/g.