Publications by authors named "Fernanda Ferreira Mendonca"

Article Synopsis
  • Breast cancer is a major public health concern, and recent research has highlighted the role of specific bioactive peptides from laminin-111 in tumor development.
  • This study focuses on three peptides (IKVAV, YIGSR, KAFDITYVRLKF) synthesized and radiolabeled for use as targeting agents in breast cancer.
  • Two of the peptides (YIKVAV and YIGSR) showed good stability and tumor-targeting ability in experiments, making them promising candidates for future breast cancer treatments, while KAFDITYVRLKF was excluded due to poor performance.
View Article and Find Full Text PDF

Human bacterial infections significantly contribute to the increase in healthcare-related burdens. This scenario drives the study of novel techniques for the early and precise diagnosis of infectious processes. Some alternatives include Nuclear Medicine- and Molecular Imaging-based strategies.

View Article and Find Full Text PDF

The expression of prostate-specific membrane antigen (PSMA) is upregulated in prostate cancer (PCa) cells and PSMA-ligands have been radiolabeled and used as radiopharmaceuticals for targeted radionuclide therapy (TRT), single photon emission computed tomography (SPECT) or positron emission tomography (PET) molecular imaging, and radioguided surgery in PCa patients. Herein, we aimed at radiolabeling the PSMA-I&S cold kit with Tc, resulting in a radiopharmaceutical with high radiochemical yield (RCY) and stability for SPECT imaging and radioguided surgery in PCa malignancies. Various pre-clinical assays were conducted to evaluate the [Tc]Tc-PSMA-I&S obtained by the cold kit.

View Article and Find Full Text PDF