Publications by authors named "Fernanda Fernandes de Souza"
Article Synopsis
- Type 2 diabetes mellitus is becoming a major global health issue, expected to nearly double in prevalence from 194 million in 2003 to 333 million by 2025, with 90%-95% of cases being type 2.
- New research focuses on developing dual inhibitors for type 2 diabetes through synthesizing ester and triazole derivatives of p-coumaric acid, using methods like Williamson synthesis and Microwave-assisted click reaction.
- These synthesized compounds were tested and showed effective inhibition against two key enzymes, GSK-3β kinase and DPP-IV, indicating that p-coumaric acid derivatives are promising candidates for new diabetes treatments.
The use of various herbs and their compounds has been a strategy widely used in the fight against various human diseases. For example, rosmarinic acid, a bioactive phenolic compound commonly found in Rosemary plants ( Labiatae), has multiple therapeutic benefits in different diseases, such as cancer. Therefore, the study aimed to evaluate and the inhibition potential of the enzyme Elastase from the porcine pancreas by rosmarinic acid isolated from the plant species Linn.
View Article and Find Full Text PDFComprehensive analysis of gene in hereditary hemochromatosis and in diseases associated with acquired iron overload.
World J Hepatol
February 2019
Background: Patients with hepatitis C virus (HCV) and hepatocellular carcinoma (HCC) may or not develop iron overload (IO), which is associated with worst prognosis, because can cause serious damage to organs. gene controls the iron uptake from gut, particularly in patients with hereditary hemochromatosis (HH).
Aim: To identify associations between coding region in patients exhibiting hereditary hemochromatosis and in diseases associated with acquired IO.