Publications by authors named "Fernanda Dos Santos Moreira"
Objectives: To investigate the potential effect of fatty acid synthase (FASN) inhibitor orlistat to enhance the effectiveness of chemotherapy drugs widely used to treat oral squamous cell carcinomas (OSCC), such as 5-fluorouracil, cisplatin, and paclitaxel.
Methods: The OSCC SCC-9 LN-1 metastatic cell line, which expresses high levels of FASN, was used for drug combination experiments. Cell viability was analyzed by crystal violet staining and automatic cell counting.
Article Synopsis
- Neuroblastoma is the most common solid cancer found outside the brain in infants, often originating in the adrenal gland, but it rarely spreads to the head and neck area, as seen in two reported cases where mandibular swelling indicated advanced disease.
- The first case involves a 4-year-old boy with painful swelling in the left jaw and destructive lesions confirmed through imaging, while the second case features a 3-year-old boy with swelling in the right jaw that also showed significant bone destruction.
- Both cases displayed aggressive tumor characteristics through microscopic analysis and high proliferation rates, leading to treatment involving chemotherapy and surgery to manage the cancer and its spread to multiple skeletal sites.