Publications by authors named "Fernanda Dittrich Oliveira"
Background: ZEB1, a core transcription factor involved in epithelial-mesenchymal transition (EMT), is associated with aggressive cancer cell behavior, treatment resistance, and poor prognosis across various tumor types. Similarly, the expression and activity of CD73, an ectonucleotidase implicated in adenosine generation, is an important marker of tumor malignancy. Growing evidence suggests that EMT and the adenosinergic pathway are intricately linked and play a pivotal role in cancer development.
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- Epithelial-mesenchymal transition (EMT) plays a crucial role in cancer progression, invasion, and resistance to therapy, making it an important target for cancer research.
- The CD73 enzyme has been linked to EMT, as it produces adenosine, which influences cell adhesion and migration, as well as having immunosuppressive effects.
- An analysis of RNA sequencing data identified a strong correlation between EMT scores and the expression of CD73 and CD39 in various cancers, especially prostate adenocarcinoma, indicating that the interplay between EMT and the adenosine signaling pathway varies by tumor context and could lead to new treatment approaches.