Publications by authors named "Fernanda Cunha Jacome"

Article Synopsis
  • Dengue is caused by four serotypes of the dengue virus (DENV-1 to -4), with DENV-4 being the least understood and often leading to complications like acute kidney injury in severe cases.
  • This study aimed to explore how experimental infection with DENV-4 affects kidney tissue in adult BALB/c mice, using intravenous infection and subsequent analysis of the kidneys.
  • Findings showed viral presence and significant kidney damage, including inflammation, glomerular enlargement, and necrosis of tubular cells, suggesting that while the kidney may not be a primary target for the virus, it still suffers damage from the infection.
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Dengue virus (DENV) infection by one of the four serotypes (DENV-1 to 4) may result in a wide spectrum of clinical manifestations, with unpredictable evolution and organ involvement. Due to its association with severe epidemics and clinical manifestations, DENV-2 has been substantially investigated. In fact, the first emergence of a new lineage of the DENV-2 Asian/American genotype in Brazil (Lineage II) in 2008 was associated with severe cases and increased mortality related to organ involvement.

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Ever since its brief introduction in the Brazilian territory in 1981, dengue virus serotype 4 (DENV-4) remained absent from the national epidemiological scenario for almost 25 years. The emergence of DENV-4 in 2010 resulted in epidemics in most Brazilian states. DENV-4, however, remains one of the least studied among the four DENV serotypes.

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Dengue virus type 2 (DENV-2) is, traditionally, the most studied serotype due to its association with explosive outbreaks and severe cases. In Brazil, almost 20 years after the first introduction in the 1990s, a new lineage (Lineage II) of the DENV-2 Asian/American genotype emerged and caused an epidemic with severe cases and hospitalizations. Severe dengue includes multiple organ failure, and renal involvement can be potentially related to increased mortality.

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Dengue (DEN) is the most prevalent arbovirus among humans, and four billion people live at risk of infection. The clinical manifestations of DEN are variable, and the disease may present subclinically or asymptomatically. A quarter of patients develop classical dengue (CD) or severe dengue (SD), which is potentially lethal and involves vascular permeability changes, severe hemorrhage and organ damage.

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Background: The impact of arbovirus cocirculation in Brazil is unknown. Dengue virus (DENV) reinfection may result in more intense viraemia or immunopathology, leading to more severe disease. The Zika virus (ZIKV) epidemic in the Americas provided pathogenicity evidence that had not been previously observed in flavivirus infections.

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Platelets play a role in hemostasis, coagulation, angiogenesis, inflammation and immune response is one of the most affected cells in dengue. Here we describe some aspects of platelets by observing their specific circulating mediators, the ability to interact with the virus and morphological consequences of this interaction, activation markers and intraplatelet protein contents in dengue. We conducted this study using dengue-patients as well as healthy donors.

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Article Synopsis
  • The absence of an effective animal model for dengue research hinders vaccine and drug development, making this study significant.
  • Prior research showed that BALB/c mice are susceptible to dengue viruses 1 and 2, and this study extends the investigation to DENV-4 by infecting these mice and analyzing their saliva.
  • The study successfully detected DENV-4 RNA in the saliva of infected mice, highlighting a correlation to human infection, even though saliva testing is not traditionally used for dengue diagnosis.
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Zika virus (ZIKV) is a member of the flavivirus genus, and its genome is approximately 10.8 kilobases of positive-strand RNA enclosed in a capsid and surrounded by a membrane. Studies on the replication dynamics of ZIKV are scarce, which limits the development of antiviral agents and vaccines directed against ZIKV.

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