Real-time redox monitoring of a nitrosyl ruthenium complex acting as NO-donor agent in a single A549 cancer cell with multiplex Fourier-transform infrared microscopy.

Multiplex Fourier-transform infrared microscopy (μFT-IR) helped to monitor trans-[Ru(NO) (NH) (isn)](I), uptake by A549 lung carcinoma cell, as well as the generation of its product, nitric oxide (NO), inside the cell. Chronoamperometry with NO-sensor and μFT-IR showed that exogenous NADH and the A549 cell induced the NO release redox mechanism. Chemical imaging confirmed that (I) was taken up by the cell, and that its localization coincided with its consumption in the cellular environment within 15 min of exposure.

An intravenous implantable glucose/dioxygen biofuel cell with modified flexible carbon fiber electrodes.

An intravenous implantable glucose/dioxygen hybrid enzyme-Pt micro-biofuel cell (BFC) was investigated. In this miniaturized BFC, a flexible carbon fiber (FCF) microelectrode modified with neutral red redox mediator and glucose oxidase was used as the bioanode, and an FCF modified with platinum nanoparticles stabilized on PAMAM-G4 dendrimer was used as the cathode. In vitro experiments conducted using the BFC in a phosphate buffer solution (50 mmol L(-1), pH = 7.