Evaluation of the C3435T polymorphism in the MDR1 gene in patients with hepatocellular carcinoma.

Introduction: Considering the high prevalence of liver tumors and the impact on patient survival, a greater understanding of the biological behavior of those tumors if of great importance. The multidrug resistance gene (MDR1) may present as single nucleotide polymorphism (SNP) which can affect the expression and activity of P-glycoprotein (Pgp), and high expression of Pgp has been associated with a worse prognosis in affected patients.

Objective: To correlate the C3435T polymorphism in the MDR1 gene with the immunohistochemical expression of Pgp.

[Relationship between portal pressure gradient and ascites in cirrhotic patients].

Context: Portal hypertension plays an important role in the pathogenesis of ascites.

Objectives: To evaluate the hepatic venous pressure gradient and the presence of ascites in cirrhotic patients.

Methods: Eighty-three patients with cirrhosis were evaluated.

[Correlation between platelet blood levels and the hepatic venous pressure gradient among patients with cirrhosis].

Background: Determination of hepatic venous pressure gradient is the main method used to assess portal pressure. Recently, platelet blood levels has been indicated as a non-invasive marker of the presence of portal hypertension.

Aim: To correlate platelet blood levels with the hepatic venous pressure gradient among patients with cirrhosis.