Intrahepatic biliary stone disease is a difficult condition to treat, due to anatomical complexity of biliary tract, association with colestasis, and high recurrence rates, with potential short- and long-term complications, such as cholangitis and secondary biliary cirrhosis. Removal of biliary stones via intraductal access can be achieved endoscopically or percutaneously, with preference for cholangioscopy-guided laser lithotripsy in complex cases. The surgical approach, despite its prolonged results, is a more invasive and risky procedure.
View Article and Find Full Text PDFIn this study, we investigated the therapeutic potential of bone marrow mononuclear cells (BMCs) in a model of epilepsy induced by pilocarpine in rats. BMCs obtained from green fluorescent protein (GFP) transgenic mice or rats were transplanted intravenously after induction of status epilepticus (SE). Spontaneous recurrent seizures (SRS) were monitored using Racine's seizure severity scale.
View Article and Find Full Text PDFThe degradation of natural resources is increasing in alarming numbers, especially water sources that is constant changes in its quality. Because of this, more and more people come using groundwater for human consumption, but the big problem is contamination by these pathogenic microorganisms. The purpose of this study was to evaluate the microbiological quality of groundwater districts in the Extreme West of Santa Catarina, Brazil.
View Article and Find Full Text PDF