Vancomycin-modified nitrogen and chloride doped carbon dots and their application as a Staphylococcus aureus probe.

In this research, N, Cl-doped carbon dots (N, Cl-CDs) were prepared in choline chloride-glycerol deep eutectic solvent (DES) by microwave method. N, Cl-CDs surface was modified with vancomycin for detection of Staphylococcus aureus (S. aureus) bacteria in the range of 10-10 colony-forming unit per milliliter (CFU/mL).

Fluorescence turn off-on detection of Co and enrofloxacin by N, Cl-carbon dots prepared in deep eutectic solvent and study of their photocatalytic antibacterial activity.

Nitrogen, chloride doped carbon dots (N, Cl-CDs) were synthesized in deep eutectic solvent. TEM, XRD, FT-IR, XPS, EDAX, UV-Vis and fluorescence were used for characterization. Quantum yield and average size of N, Cl-CDs were 38.

A global method for fast simulations of molecular dynamics in multiscale agent-based models of biological tissues.

Agent-based models (ABMs) are a natural platform for capturing the multiple time and spatial scales in biological processes. However, these models are computationally expensive, especially when including molecular-level effects. The traditional approach to simulating this type of multiscale ABM is to solve a system of ordinary differential equations for the molecular events per cell.

Comparison of Carbon Dots Prepared in Deep Eutectic Solvent and Water/Deep Eutectic Solvent: Study of Fluorescent Detection of Fe and Cetirizine and their Photocatalytic Antibacterial Activity.

In this study, two solvents (deep eutectic and water/deep eutectic solvents) were used for N-doped carbon dots (N-CDs) preparation by microwave irradiation. The solvent can influence surface chemical composition, quantum yield, morphology, and fluorescence of CDs. N-CDs synthesized in water/deep eutectic solvent (DES) had better quantum yield (24.

Sensitive fluorescence detection of atorvastatin by doped carbon dots synthesized in deep eutectic media.

Fluorescence properties of nanoparticles can be influenced by solvent. In this work, carbon dots (CDs) were synthesized in deep eutectic solvent by microwave assisted method. Quantum yield (QY) and size of the synthesized CDs were 41.

Models Accurately Predict Response for IL6 Blockade in Head and Neck Cancer.

Malignant features of head and neck squamous cell carcinoma (HNSCC) may be derived from the presence of stem-like cells that are characterized by uniquely high tumorigenic potential. These cancer stem cells (CSC) function as putative drivers of tumor initiation, therapeutic evasion, metastasis, and recurrence. Although they are an appealing conceptual target, CSC-directed cancer therapies remain scarce.

Luminescent, low-toxic and stable gradient-alloyed Fe:ZnSe(S)@ZnSe(S) core:shell quantum dots as a sensitive fluorescent sensor for lead ions.

In this paper, an aqueous-based approach is introduced for facile, fast, and green synthesis of gradient-alloyed Fe-doped ZnSe(S)@ZnSe(S) core:shell quantum dots (QDs) with intense and stable emission. Co-utilization of co-nucleation and growth doping strategies, along with systematic optimization of emission intensity, provide a well-controllable/general method to achieve internally doped QDs (d-dots) with intense emission. Results indicate that the alloyed ZnSe(S)@ZnSe(S) core:shell QDs have a gradient structure that consists of a Se-rich core and a S-rich shell.

A mathematical model for IL-6-mediated, stem cell driven tumor growth and targeted treatment.

Targeting key regulators of the cancer stem cell phenotype to overcome their critical influence on tumor growth is a promising new strategy for cancer treatment. Here we present a modeling framework that operates at both the cellular and molecular levels, for investigating IL-6 mediated, cancer stem cell driven tumor growth and targeted treatment with anti-IL6 antibodies. Our immediate goal is to quantify the influence of IL-6 on cancer stem cell self-renewal and survival, and to characterize the subsequent impact on tumor growth dynamics.

A two-strain TB model with multiple latent stages.

A two-strain tuberculosis (TB) transmission model incorporating antibiotic-generated TB resistant strains and long and variable waiting periods within the latently infected class is introduced. The mathematical analysis is carried out when the waiting periods are modeled via parametrically friendly gamma distributions, a reasonable alternative to the use of exponential distributed waiting periods or to integral equations involving ``arbitrary'' distributions. The model supports a globally-asymptotically stable disease-free equilibrium when the reproduction number is less than one and an endemic equilibriums, shown to be locally asymptotically stable, or l.

Mass Media and the Contagion of Fear: The Case of Ebola in America.

Background: In the weeks following the first imported case of Ebola in the U. S. on September 29, 2014, coverage of the very limited outbreak dominated the news media, in a manner quite disproportionate to the actual threat to national public health; by the end of October, 2014, there were only four laboratory confirmed cases of Ebola in the entire nation.