Genetic, immunologic, and clinical features of 830 patients with Mendelian susceptibility to mycobacterial diseases (MSMD): A systematic review.

Background: Mendelian susceptibility to mycobacterial diseases (MSMD) is a rare clinical syndrome characterized by vulnerability to weakly virulent mycobacterial species, including Bacillus Calmette-Guérin (BCG) vaccines and environmental mycobacteria.

Objective: We sought to perform a systematic review of the genetic, immunologic, and clinical findings for reported patients with MSMD.

Methods: We searched PubMed, Web of Science, and Scopus databases for publications in English relating to MSMD.