Publications by authors named "Fereshteh B Darvishi"
Sarcopenia, the pathological age-related loss of muscle mass and strength, contributes to physical decline, frailty, and diminished healthspan. The impact of sarcopenia is expected to rise as the aging population grows, and treatments remain limited. Therefore, novel approaches for enhancing physical function and strength in older adults are desperately needed.
View Article and Find Full Text PDFAmyotrophic Lateral Sclerosis (ALS) is a group of sporadic and genetic neurodegenerative disorders that result in losses of upper and lower motor neurons. Treatment of ALS is limited, and survival is 2-5 years after disease onset. While ALS can occur in younger individuals, the risk significantly increases with advancing age.
View Article and Find Full Text PDFArticle Synopsis
- * Increasing the expression of an alternative NADH dehydrogenase, NDI1, can improve the NAD/NADH balance, enhance SIRT3 activity, and reduce tumor formation in cells lacking neurofibromin.
- * The research suggests that targeting mitochondrial metabolism, specifically by manipulating NAD levels and enhancing succinate dehydrogenase activity, may offer new treatment strategies for tumors associated with neurofibromin loss.