Kinetic stability of all-in-one parenteral nutrition admixtures in the presence of high dose Ca2+ additive under clinical application circumstances.

Background: TPN infusions are usually administered during a treatment period of 10-24 hours per day due to the metabolic capacity of the liver. During this time interval physicochemically stable TPN solution (emulsion) is needed for the treatment. The purpose of the present study was to examine how the kinetic stability features of ready-made total parenteral nutrition admixtures containing olive oil and soybean oil will change under the usage-modeling 24-hour application with and without overdose Ca2+.

[Colloid-physical characterization of supramolecular drug delivery systems].

Cyclodextrins are well-known biocompatible oligosaccharides capable of forming inclusion complexes with suitable guest molecules. They can be expediently used as solubilizers for hydrophobic pharmacon molecules in aqueous solutions. In this study, the effect of colloidal and non-colloidal additives on the solubility of statins is described.

Enhancement of drug solubility in supramolecular and colloidal systems.

Statins, as efficient HMG-CoA (3-hydroxy-3-methylglutaryl-coenzyme-A) reductase inhibitors are widely used in the management of cardiovascular diseases. Interactions in aqueous solutions between highly lipophilic statins and cyclodextrins (CDs) in the absence and the presence of a dissolved polymer or its monomeric compound, respectively, were studied. The solubility of lovastatin and simvastatin at various temperatures and pHs were investigated by phase-solubility measurements.

Tracking of the kinetic stability of 2 types of total nutrient admixtures containing different lipid emulsions.

The physical stability of 2 types of total nutrient admixtures was studied as a function of storage time and temperature. One of them contained only structured triglycerides and the other exclusively long-chain triglycerides as lipid components. To evaluate the possible changes in the kinetic stability of the emulsions and in the surface characteristics of the droplets during storage, particle size analysis, zeta potential, and dynamic surface tension measurements were performed.

[Interactions in solution between cyclodextrins and statins].

Cyclodextrins (CDs) are cyclic oligosaccharides, capable of forming inclusion complexes with hydrophobic molecules in aqueous solution and therefore, of improving the bioavailability of many drugs. They are biocompatible with living cells and do not cause toxic side effects. In this study, interactions in aqueous solutions between chemically different CDs and lovastatin and simvastatin, respectively, were investigated.

The effect of structured triglycerides on the kinetic stability of total nutrient admixtures.

Purpose: The physical stability of two types of total parenteral nutrient (TPN) admixtures was studied as a function of storage time and temperature. One of them contained only structured triglycerides and the other exclusively long-chain triglycerides as lipid components.

Methods: Droplet size of the mixtures was followed by photon correlation spectroscopy for 10 days.

Influence of the chain composition on the thermodynamic properties of binary and ternary polymer solutions.

Thermodynamic properties of binary and ternary polymer solutions (one or two uncharged polymers in one solvent) were studied. Poly(vinyl pyrrolidone) (PVP), fully hydrolyzed poly(vinyl alcohol) (PVA) homopolymers, and water-soluble poly(vinyl alcohol-co-vinyl acetal, -vinyl propional, and -vinyl butiral) copolymers with various acetal content and chain structure, respectively, were used in the experiments. The hydrophilic/hydrophobic character of the PVA-based macromolecules and their compatibility with the PVP homopolymer were systematically regulated by changing the chemical structure of the copolymers (acetal content and/or length of side chains).

In vitro kinetic study of absorbency of retraction cords.

Statement Of Problem: The soaking time required for liquid uptake by retraction cords is a crucial factor in the successful gingival retraction procedure.

Purpose: The aim of this investigation was to determine the optimal soaking time for 3 retraction cords of different thickness to ensure adequate uptake of the hemostatic solution.

Material And Methods: Braided ULTRAPAC retraction cords of 3 different thicknesses (No.

[Kinetic study of the liquid uptake of retraction cords].

The soaking time ensured for the liquid uptake of retraction cords is a crucial factor in the successful gingival retraction procedure. The aim of the present investigations was to determine the optimal soaking time for three cords of different thickness. The capability of liquid uptake of the cords was measured by a gravimetric method using four different sulcus retraction solutions.