Association between lifetime endogenous estrogen exposure and body composition metrics in postmenopausal women: findings from the Tehran Lipid and Glucose Study.

Background: The role of endogenous estrogen exposure (EEE) in shaping body composition and its implications for cardiometabolic health remain understudied despite its potential significance. This cross-sectional study aimed to investigate the association between EEE and body composition indices among postmenopausal women.

Methods: Data were obtained from the Tehran Lipid and Glucose Study (TLGS), including 960 women aged over 40 years.

Excessive exposure to nitrate and nitrite boosts progression of isolated impaired fasting glucose to type 2 diabetes: a cohort study.

Objectives: This cohort study investigated the possible association of dietary nitrate (NO)/nitrite (NO) intake and risk of progression to type 2 diabetes (T2D) across different phenotypes of prediabetes (Pre-DM).

Methods: A total of 1586 adults diagnosed with Pre-DM [i.e.

Fracture incidence in women: the impact of reproductive characteristics.

Background: Although endogenous estrogen exposure, influenced by reproductive factors (RFs), is negatively associated with fracture risk, there is limited and conflicting information on the association between these factors and the incidence of fractures. This study aimed to evaluate the association between RFs and fracture incidence (FXI) separately.

Methods: This longitudinal study commenced in 1999 and concluded in 2021.

Progression to diabetes and regression to normoglycemia in pre-diabetic subjects: results from a pragmatic community trial in a middle-income country.

Purpose: The incidence of prediabetes has been on the rise, indicating a growing public health concern, as individuals with prediabetes are at higher risk of developing type 2 diabetes. This study aimed to determine the effects of simple interventions on the regression of pre-diabetes status into normoglycemia and also prevent progression to diabetes in a pragmatic community trial.

Methods: A total of 2073 (761 intervention; 1,312 controls) participants with pre-diabetes were included in the present secondary data analysis; cases with diabetes or normoglycemia were identified during nine years of follow-up.

Association between metabolic phenotypes and incident pre-sarcopenia: 3 years follow-up of Tehran Lipid and Glucose Study.

Objectives: In the context of musculoskeletal health, the emergence of pre-sarcopenia as a precursor to sarcopenia has garnered attention for its potential insights into early muscle loss. We explored the association between different metabolic phenotypes of obesity, and the incidence of pre-sarcopenia over a 3-year follow-up in a cohort from the Tehran Lipid and Glucose Study (TLGS).

Methods: In this 3-year longitudinal study, 2257 participants were categorized into four groups based on their BMI and metabolic status: metabolically healthy normal weight (MHNW), metabolically healthy overweight/obese (MHO), metabolically unhealthy normal weight (MUNW), and metabolically unhealthy overweight/obese (MUO).

Body composition analysis in women with polycystic ovary syndrome: a cross-sectional study from the Tehran Lipid and Glucose Study (TLGS).

Background: Obesity is associated with the development of polycystic ovarian syndrome (PCOS), a complex endocrine disorder. However, the correlation between body composition and PCOS in women has not been thoroughly investigated. This study aimed to examine body composition using bioelectrical impedance analysis (BIA) in women with and without PCOS in a population-based study within the Tehran Lipid and Glucose Study (TLGS).

Health-related quality of life in adults with metabolic syndrome: a multi-level analysis of family and individual level variation.

Purpose: The current study aimed to investigate the associations between metabolic syndrome (MetS) with health-related quality of life (HRQoL) using multilevel analysis among the Iranian adult population.

Methods: This cross-sectional study was conducted in the framework of the Tehran Lipid and Glucose Study (TLGS). Participants were 6113 participants (3318 women and 2795 men) aged≥20 years of the TLGS seventh phase who had completed data on HRQoL and MetS.

Effect of 3-year changes in adiposity measures on the pre-diabetes regression and progression: a community-based cohort study.

Aim: We assessed the impact of a 3-year change-percent in adiposity measures on regression and pre-diabetes (Pre-DM) progression among Iranian adults.

Methods: Three-year change-percent in body weight (BW), body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), and visceral adiposity index (VAI) were calculated for 1458 Pre-DM subjects (mean age of 53.0 ± 13.

Blood pressure status, quality of life, and emotional states in adults with different disease awareness and treatment adherence.

This study aimed to examine the association between blood pressure (BP) with health-related quality of life (HRQoL) and emotional states, considering the disease awareness and commitment to treatment among the Iranian adult population. This cross-sectional study uses the data of 7257 and 2449 individuals aged ≥ 20 who had completed data on HRQoL and emotional states, respectively. Linear and logistic regression were used to evaluate the mentioned association.

Female Reproductive System and Thyroid Dysfunction: Findings from a 12-Year Follow-Up in the Tehran Thyroid Study.

The impact of thyroid dysfunction (TD) on the female reproductive system has been extensively documented. While there is evidence suggesting that alteration in female reproductive status may affect thyroid function, conflicting results have prevented definitive conclusions. This study aimed to investigate the associations of parity, spontaneous abortion (mentioned as abortion throughout this study), and menopause status with the prevalence and incidence of TD.

The trend of correlation changes of macronutrient intakes among different familial pairs: a prospective study among participants of Tehran Lipid and Glucose Study.

Background/aim: Familial resemblance in dietary patterns has been a subject of interest, with both genetic and environmental factors playing crucial roles. This study aims to investigate trends in macronutrient intake correlations over a 9-year period among different familial pairs, including parent-offspring, siblings, and spouses, using data from the Tehran Lipid and Glucose Study (TLGS).

Methods: This longitudinal study, conducted within the framework of the TLGS, analyzed data from 1,814 families over a 9-year period.

Cardio-Metabolic Risk Profile of Women With Endometriosis: A Population-Based Study.

Aims: Endometriosis (EM) and metabolic disorders are frequent health problems among reproductive-aged women worldwide. Cardio-metabolic risk profile of women with EM is not well understood. We aimed to investigate the cardio-metabolic risk profile of Iranian reproductive-aged women with EM.

Linking extent of return to fasting state after oral glucose tolerance test to future risk of prediabetes and type 2 diabetes: Insights from the TLGS.

Aims: To assess the risk of difference between 2 h post-load plasma glucose (2 h-PG) and fasting plasma glucose (FPG) on incident prediabetes/type 2 diabetes (T2DM) among normoglycemic individuals.

Methods: Among 4,971 individuals aged ≥20 years, the associations of the difference between 2 h-PG and FPG with outcomes were examined using multivariable-adjusted Cox regression analysis. Participants were categorized into three groups: a low post-load group (2 h-PG ≤ FPG, as the reference group); a high post-load group (2 h-PG > FPG and ≥75th percentile of the difference); and a medium post-load group (2 h-PG > FPG and <75th percentile of the difference), which was further categorized into three groups by equal ranges.