Stenosis progression after surgical injury in Milan hypertensive rat carotid arteries.

Background: Milan hypertensive rats (MHS) are characterised by an increase in renal sodium reabsorption mainly related to adducin mutations. Interest in this model relies on the genetic link between adducin polymorphisms and primary hypertension, observed also in a subset of patients.

Objectives: To investigate the molecular and morphological events involved in carotid stenosis and triggered by surgery in MHS model.

Chronic peripheral ouabain treatment affects the brain endothelin system of rats.

Background: Chronically administered ouabain increases the content of ouabain in several brain areas that are closely related to central cardiovascular regulation. However, the pattern of central changes induced by chronic infusion of ouabain is not completely understood.

Objectives: To investigate whether chronic peripheral ouabain treatment affects the brain endothelin system.