Publications by authors named "Ferdinand Fandrei"
Ionic liquids (ILs) have great potential to facilitate transdermal and topical drug delivery. Here, we investigated the mechanism of action of amphiphilic ILs 1-methyl-3-octylimidazolium bromide (CMIM) and 3-dodecyl-1-methylimidazolium bromide (CMIM) in skin barrier lipid models in comparison to their complex effects in human skin. CMIM incorporated in a skin lipid model was a better permeation enhancer than CMIM for water and model drugs, theophylline and diclofenac.
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- Omega-O-acyl ceramides, like Cer[EOS], are critical for maintaining the skin barrier, preventing water loss, and blocking unwanted substances.
- Researchers synthesized Cer[EOS] with specific labeled segments to study its behavior in skin lipid models using solid-state NMR, revealing unexpected molecular movement compared to other lipids.
- The findings suggest that the skin barrier has a unique layered structure that balances rigidity and fluidity, allowing it to be both protective and adaptable for functions like elasticity and enzyme accommodation.
Desulfation of cholesterol sulfate (CholS) to cholesterol (Chol) is an important event in epidermal homeostasis and necessary for stratum corneum (SC) barrier function. The CholS/Chol ratio decreases during SC maturation but remains high in pathological conditions, such as X-linked ichthyosis, characterized by dry and scaly skin. The aim of this study was to characterize the influence of the CholS/Chol molar ratio on the structure, dynamics, and permeability of SC lipid model mixtures.
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