[Experience of a Rapid Diagnostic and Short Stay Unit implemented in Argentina].

Introduction: Rapid diagnostic units (RDUs) represent an alternative to conventional hospitalization diagnosis, enabling outpatient care for patients with suspected potentially severe disease. The first year of operation of a Rapid Diagnostic and Short Stay Unit (RDSSU) is described.

Materials And Methods: Retrospective study involving 696 patients, documenting 739 events defined as each patient's entry into the RDU for specific reasons.

Application of Surface Stress-Driven Model for Higher Vibration Modes of Functionally Graded Nanobeams.

This paper employs a surface stress-driven nonlocal theory to investigate the synergistic impact of long-range interaction and surface energy on higher vibration modes of Bernoulli-Euler nanobeams made of functionally graded material. It takes into account surface effects such as the surface modulus of elasticity, residual surface stresses, surface density, and rotary inertia. The governing equation is derived through the application of Hamilton's principle.

Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation.

TREM2 is an innate immune receptor expressed by microglia in the adult brain. Genetic variation in the TREM2 gene has been implicated in risk for Alzheimer's disease and frontotemporal dementia, while homozygous TREM2 mutations cause a rare leukodystrophy, Nasu-Hakola disease (NHD). Despite extensive investigation, the role of TREM2 in NHD pathogenesis remains poorly understood.

Schwann Cell Remyelination in the Multiple Sclerosis Central Nervous System.

Multiple sclerosis (MS) is a central nervous system (CNS) demyelinating disease. Failure to remyelinate successfully is common in MS lesions, often with consequent neuronal/axonal damage. CNS myelin is normally produced by oligodendroglial cells.

Reducing infection risk in multiple sclerosis and neuromyelitis optica spectrum disorders: a Brazilian reference center's approach.

Background: Multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD) are the most common autoimmune diseases of the central nervous system (CNS). They present chronic relapsing courses that demand treatment with disease-modifying drugs (DMDs) to prevent inflammatory activity. Disease-modifying drugs lead to immunomodulation or immunosuppression through diverse mechanisms (e.

Theoretical Modelling of the Degradation Processes Induced by Freeze-Thaw Cycles on Bond-Slip Laws of Fibres in High-Performance Fibre-Reinforced Concrete.

High-performance fibre-reinforced concrete (HPFRC) is a composite material in which the advantages of fibre-reinforced concrete (FRC) are combined with those of a high-performance concrete (HPC), which mitigates the weaknesses of conventional concrete and improves its overall performance. With the aim to reduce the long-term maintenance costs of structures, such as heavily loaded bridges, HPFRC is highly recommended due to its major durability performance. Specifically, its good antifreezing property makes it suitable for application in cold regions where cyclic freeze-thaw conditions cause the concrete to degrade.

Application of the Higher-Order Hamilton Approach to the Nonlinear Free Vibrations Analysis of Porous FG Nano-Beams in a Hygrothermal Environment Based on a Local/Nonlocal Stress Gradient Model of Elasticity.

Nonlinear transverse free vibrations of porous functionally-graded (FG) Bernoulli-Euler nanobeams in hygrothermal environments through the local/nonlocal stress gradient theory of elasticity were studied. By using the Galerkin method, the governing equations were reduced to a nonlinear ordinary differential equation. The closed form analytical solution of the nonlinear natural flexural frequency was then established using the higher-order Hamiltonian approach to nonlinear oscillators.

Retrospective Study of Canine Peripheral Lymphadenopathy in a Mediterranean Region: 130 Cases.

Lymphadenopathy is a common clinical concern in dogs. Causes of lymphadenopathy include neoplasia, infection, and immune-mediated diseases. Seasonal infectious diseases should be considered as a potential cause of lymphadenopathy in endemic regions, such as the Mediterranean region.

Increased SARS-CoV-2 seroprevalence in healthy blood donors after the second pandemic wave in South-Eastern Italy: evidence for asymptomatic young donors as potential virus spreaders.

Background: Italy experienced SARS-CoV-2 spread during the second wave and the southern regions were severely affected. In this prospective study, we assessed the changes in SARS-CoV-2 seroprevalence rates in non-vaccinated blood donors to evaluate the spread of SARS-CoV-2 among healthy individuals in our geographical area.

Methods: 8,183 healthy blood donors visiting the Transfusion Centre at the University Hospital "Riuniti" of Foggia (Italy) to donate blood from May 2020 to March 2021 were tested twice for anti-SARS-CoV-2 antibodies by Ortho Clinical Diagnostics VITROS 3600 through anti-SARS-CoV-2 Total and IgG reagent kit.

Dynamic Response of Multilayered Polymer Functionally Graded Carbon Nanotube Reinforced Composite (FG-CNTRC) Nano-Beams in Hygro-Thermal Environment.

This work studies the dynamic response of Bernoulli-Euler multilayered polymer functionally graded carbon nanotubes-reinforced composite nano-beams subjected to hygro-thermal environments. The governing equations were derived by employing Hamilton's principle on the basis of the local/nonlocal stress gradient theory of elasticity (L/NStressG). A Wolfram language code in Mathematica was written to carry out a parametric investigation on the influence of different parameters on their dynamic response, such as the nonlocal parameter, the gradient length parameter, the mixture parameter and the hygro-thermal loadings and the total volume fraction of CNTs for different functionally graded distribution schemes.

Hygro-Thermal Vibrations of Porous FG Nano-Beams Based on Local/Nonlocal Stress Gradient Theory of Elasticity.

In this manuscript the dynamic response of porous functionally-graded (FG) Bernoulli-Euler nano-beams subjected to hygro-thermal environments is investigated by the local/nonlocal stress gradient theory of elasticity. In particular, the influence of several parameters on both the thermo-elastic material properties and the structural response of the FG nano-beams, such as material gradient index, porosity volume fraction, nonlocal parameter, gradient length parameter, and mixture parameter is examined. It is shown how the proposed approach is able to capture the dynamic behavior of porous functionally graded Bernoulli-Euler nano-beams under hygro-thermal loads and leads to well-posed structural problems of nano-mechanics.

Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis.

Amyotrophic Lateral Sclerosis (ALS) is a fatal disease characterized by the degeneration of upper and lower motor neurons (MNs). We find a significant reduction of the retromer complex subunit VPS35 in iPSCs-derived MNs from ALS patients, in MNs from ALS post mortem explants and in MNs from SOD1G93A mice. Being the retromer involved in trafficking of hydrolases, a pathological hallmark in ALS, we design, synthesize and characterize an array of retromer stabilizers based on bis-guanylhydrazones connected by a 1,3-phenyl ring linker.

Management of central nervous system demyelinating diseases during the coronavirus disease 2019 pandemic: a practical approach.

Background: The novel coronavirus disease 2019 (COVID-19) pandemic poses a potential threat to patients with autoimmune disorders, including multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). Such patients are usually treated with immunomodulatory or immunosuppressive agents, which may tamper with the organism's normal response to infections. Currently, no consensus has been reached on how to manage MS and NMOSD patients during the pandemic.

Multi-Material Additive Manufacturing of Sustainable Innovative Materials and Structures.

This paper highlights the multi-material additive manufacturing (AM) route for manufacturing of innovative materials and structures. Three different recycled thermoplastics, namely acrylonitrile butadiene styrene (ABS), polylactic acid (PLA), and high impact polystyrene (HIPS) (with different Young's modulus, glass transition temperature, rheological properties), have been selected (as a case study) for multi-material AM. The functional prototypes have been printed on fused deposition modelling (FDM) setup as tensile specimens (as per ASTM D638 type-IV standard) with different combinations of top, middle, and bottom layers (of ABS/PLA/HIPS), at different printing speed and infill percentage density.

Resection of the Primary Tumor in Stage IV Colorectal Cancer: When Is It Necessary?

Management of metastatic colorectal cancer requires accurate staging and multidisciplinary evaluation, leading to a consensus treatment plan with the ultimate goal of increasing survival and improving the quality of life, while taking into consideration the patient's performance status, disease burden, and goals of care. Since the introduction of multidrug chemotherapeutic regimens, survival of patients with metastatic colorectal cancer has improved. Many patients with unresectable disease are undergoing surgery for asymptomatic primary tumors despite evidence that it is usually a futile intervention.

Dynamic Phosphorylation of the Myocyte Enhancer Factor 2Cα1 Splice Variant Promotes Skeletal Muscle Regeneration and Hypertrophy.

The transcription factor MEF2C (Myocyte Enhancer Factor 2C) plays an established role in the early steps of myogenic differentiation. However, the involvement of MEF2C in adult myogenesis and in muscle regeneration has not yet been systematically investigated. Alternative splicing of mammalian MEF2C transcripts gives rise to two mutually exclusive protein variants: MEF2Cα2 which exerts a positive control of myogenic differentiation, and MEF2Cα1, in which the α1 domain acts as trans-repressor of the MEF2C pro-differentiation activity itself.

Development and feasibility of an evidence-informed self-management education program in pediatric concussion rehabilitation.

Background: Concussion is a considerable public health problem in youth. However, identifying, understanding and implementing best evidence informed recovery guidelines may be challenging for families given the vast amount of information available in the public domains (e.g.

T cells kill bacteria captured by transinfection from dendritic cells and confer protection in mice.

Dendritic cells (DCs) phagocytose, process, and present bacterial antigens to T lymphocytes to trigger adaptive immunity. In vivo, bacteria can also be found inside T lymphocytes. However, T cells are refractory to direct bacterial infection, leaving the mechanisms by which bacteria invade T cells unclear.

Incremental cost of complications in colectomy: a warranty guided approach to surgical quality improvement.

Background: We assessed the warranty cost for colectomy at a single institution, as defined by the additional cost of treating complications distributed across all patients treated.

Methods: All segmental colectomies from July 8 to June 12 were reviewed for 0, 1, 2, and ≥3 complications. Warranty cost is defined as follows: ([mean additional cost of the case with complication(s) - mean base case cost] × number of episodes)/total population.

Anastomotic leaks: technique and timing of detection.

Background: Despite the proven benefits of laparoscopic colorectal surgery, the rate of anastomotic leaks has not changed. This study looks at the time of presentation of anastomotic leaks between laparoscopic and open colectomies.

Methods: Retrospective chart review was performed between July 2008 and 2012.