Single-dose amoxicillin therapy with follow-up urine culture. Effective initial management for acute uncomplicated urinary tract infections.

To learn whether a single dose of amoxicillin is safe, effective therapy for acute uncomplicated urinary tract infections, 388 symptomatic nonpregnant women were randomly grouped to receive oral amoxicillin, either as a single 3 g dose of 250 mg three times a day for two weeks. Patients had quantitative as well as dip-slide cultures of urine and tests for antibody-coated bacteria in urine. Follow-up urine cultures were obtained one week after completion of treatment.

Influence of wall surface on the flow of blood through endothelial-lined glass tubes.

It has been proposed that the presence of endothelial cells lining small vessels decreases resistance to microcirculatory blood flow. Results of previous investigations have been inconclusive when fibrin-coated glass tubes were used to approximate the endothelial layer. Estimates of the decrease in apparent viscosity for blood flow in these tubes have ranged from near-zero to 50% when compared to flow in unlined glass tubes.

Morphometry of diabetic conjunctival blood vessels.

Photographs of the bulbar conjunctiva of 56 diabetic and 59 nondiabetic control patients were analyzed by newly developed morphometric techniques. When compared to controls diabetic patients showed: (1) decreased vascularity in the capillary bed but an increased vascularity of the venules with a volume shift in the distribution of blood into the venules; (2) an increased capillary pressure but comparable flow and, therefore, increased capillary resistance; (3) an increase in the range of background density suggesting either focal thickening of the interstitial tissue or variable amounts of fluid within the tissue; (4) a decrease in the percentage of the area occupied by microvessels; and (5) an increase in diffusion distance to all vessels.

Analgesic ingestion and chronic peptic ulcer.

The patterns of analgesic ingestion in gastric and duodenal ulcer patients were compared with those of matched community controls in order to ascertain differences that may exist between ulcer and nonulcer subjects of comparable age and sex. The differences sought concerned amounts and types of analgesics ingested. The types of analgesics studied were aspirin and acetaminophen, ingested either alone or together.

Isoenzymes of lactate dehydrogenase in human gastric mucosa and gastric carcinoma tissue.

Lactate dehydrogenase (LDH) isoenzymes were demonstrated electrophoretically in human fundic and pyloric gastric mucosae and in gastric carcinoma tissue. Fundic gastric mucosa consistently displayed a pattern with predominance of LD1, LD2, and LD3. Pyloric gastric mucosa and cancer tissue consistently had identical patterns with a predominance of LD2, LD3, and LD4, differing significantly from the LDH isoenzyme pattern of fundic mucosa.

FURTHER OBSERVATIONS ON THE GASTRIC SECRETORY DEPRESSANT IN HUMAN GASTRIC JUICE.

A gastric secretory depressant ;gastrone' has been previously found in normal gastric juice. These studies show that it is present in the neutralized gastric juice and is not destroyed by peptic digestion in one hour, indicating that this factor is not a protein and would be consistent with the view that it is related to the mucopolysaccharides in gastric juice.