Publications by authors named "Fennell R"

Article Synopsis
  • Development of user-friendly and cost-effective assays to accurately count CD4 T cells is crucial for managing HIV-1 disease and assessing treatment success.
  • The new technology features a double antibody selection process and a microfluidic chip to enhance specificity and reduce non-specific binding.
  • A portable, low-cost optical imaging system combined with an automated counting program has achieved over 90% efficiency in isolating and counting CD4 T cells.
View Article and Find Full Text PDF
Article Synopsis
  • Research on intimate partner violence (IPV) has gained attention, focusing on individual attitudes and societal norms regarding its acceptability, which may influence its prevalence.
  • A study in rural Senegal used latent class measurement models to analyze attitudes toward IPV, revealing significant differences in how men and women view its acceptability.
  • The findings indicate that traditional measurement methods may not accurately reflect attitudes toward IPV, underscoring the need for improved measurement strategies to enhance research and interventions.
View Article and Find Full Text PDF
Article Synopsis
  • Lensless biological imaging systems offer a wider field of view compared to traditional microscopes, which usually sacrifice this for higher magnification.
  • A new lens-based system aims to match the wide field of view of lensless setups by employing a unique compound lens design.
  • The study rigorously compares the two optical systems using the same imaging device and software, focusing on the essential principles required for effective biological imaging and future cost-effective designs.
View Article and Find Full Text PDF
Article Synopsis
  • A systematic literature review was conducted using PRISMA guidelines to examine factors affecting nurses' ability to provide sexual healthcare education to patients, revealing several underlying issues in nursing practice.
  • The review highlighted that inadequate knowledge, personal beliefs about privacy, discomfort discussing sexual health, and perceived organizational barriers hinder nurses from engaging with patients on this crucial topic.
  • The conclusion emphasized a lack of comprehensive sexual healthcare education in nursing, advocating for increased promotion of positive sexual health practices to reduce stigma and facilitate better conversations between nurses and patients.
View Article and Find Full Text PDF
Article Synopsis
  • Tobacco-free campuses support public health initiatives aimed at reducing tobacco use, especially among college students, but currently, only about 800 of over 6,000 U.S. colleges and universities have implemented such policies.
  • Effective enforcement of these smoke-free policies is crucial; without it, the policies can become ineffective and meaningless.
  • College administrators need to take responsibility by ensuring that violators of tobacco-free policies face consequences similar to those for violating other campus rules.
View Article and Find Full Text PDF

Crimes on college campuses can "strike fear" into the lives of those in higher education and a shooting is one of the crimes that ranks at the top of the most feared acts of violence. Maybe more direct counseling for clients who have weapons with regard to anticipatory guidance on firearms is needed. However, the debate continues with proposed legislation in different states regarding Second Amendment rights to legally carry concealed weapons on our Nation's campuses.

View Article and Find Full Text PDF

Objective: International experience is paramount in society today. However, many US citizens have little understanding of the world beyond US borders. The purpose of this qualitative study was to (i) assess the impact of a study abroad program on students and (ii) the impact on the career goals of students who completed the program.

View Article and Find Full Text PDF

BKVAN has emerged as a major morbidity in kidney transplant recipients. Among treatment options is cidofovir, which can be nephrotoxic. We previously reported that intermediate dose cidofovir could be used without significant nephrotoxicity.

View Article and Find Full Text PDF

In adult patients with ESRD, calcific uremic arteriolopathy (CUA) is an uncommon but life-threatening complication. No effective therapy exists, although anecdotal case reports highlight the use of sodium thiosulfate (STS), a calcium-chelating agent with antioxidant properties. CUA is rare in children, and STS use has not been reported.

View Article and Find Full Text PDF

Background: Catheter-related infections limit catheter survival. The success of antimicrobial therapy for the treatment of patients with hemodialysis catheter-related bacteremia (HD-CRB) depends on the infectious organisms. We determined whether the rate of positive blood culture results per tunneled catheter-days, the spectrum of bacterial isolates, and their antibiotic susceptibility changed over time in our pediatric dialysis unit.

View Article and Find Full Text PDF

We have previously reported sirolimus (SRL) pharmacokinetics (PK) in pediatric renal transplant recipients on a calcineurin inhibitor (CNI)-free protocol. We now report pediatric SRL PK in pediatric renal transplant patients receiving SRL + CNI. SRL was dosed to achieve target trough levels between 10 and 20 ng/mL.

View Article and Find Full Text PDF

BK virus allograft nephropathy (BKVAN) is a rising complication in kidney transplant recipients. Reducing immunosuppression has been the initial form of therapy in most cases, but is not always associated with improvement in graft function. Anti-viral therapy with low-dose cidofovir (0.

View Article and Find Full Text PDF

Lymphoid malignancies such as post-transplant lymphoproliferative disease (PTLD) are a major complication of solid organ transplantation. Hodgkin's lymphoma (HL) is not part of the typical spectrum of PTLD, but has rarely been reported as a separate complication. We report a case of HL occurring after previous PTLD in a renal transplant recipient.

View Article and Find Full Text PDF

Nephrogenic fibrosing dermopathy (NFD) is a rare and recently recognized sclerosing skin disorder of unknown etiology. Reported cases have occurred in patients with chronic renal failure, with or without renal replacement therapy. All previous cases have been reported in older adult patients.

View Article and Find Full Text PDF

Cat scratch disease (CSD) can lead to unexplained fever, generalized lymphadenopathy and organomegaly in immunocompetent individuals. CSD has rarely been reported in immunocompromised transplant recipients, where its clinical features would mimic the more common post-transplant lymphoproliferative disease (PTLD). We report three cases of CSD seen recently in children who had received prior kidney transplants.

View Article and Find Full Text PDF

Toxic ingestion of valproic acid is difficult to treat as no antidote exists and hemodialysis has been considered ineffective for clearance due to high protein binding of this drug. Recent reports suggest that protein binding of valproic acid is saturated at toxic levels, thereby allowing for removal of free drug by extracorporeal circuits. We describe our experiences in two children with toxic blood levels of valproic acid, in whom we were able to achieve effective clearances by extracorporeal removal without charcoal hemoperfusion.

View Article and Find Full Text PDF

This study examined perceived medication regimen characteristics as factors in levels of medication adherence among 26 African American and 42 European American pediatric renal transplant patients. Among both groups, perceived characteristics of their medication regimen, including pill size, pill taste and medication complexity, were found to have significantly low to moderate associations with medication adherence. These associations were stronger and more consistent across medication adherence measures among the African American patients.

View Article and Find Full Text PDF

Objective: To predict medication adherence among ethnically different pediatric patients with renal transplants between the ages of 6 and 20 years old, using self-regulation variables including motivation, perceived control and responsibility, and perceived support.

Methods: Twenty-six African American children and 42 Caucasian children were verbally administered the Self-Regulation of Medication Adherence Battery to assess their (1) motivation to be medication adherent, (2) perceived control of and responsibility for medication adherence, and (3) perceived support of medication adherence from their primary caregiver. Four measures were used to assess medication adherence: self-ratings, nephrologists' ratings, cyclosporine levels, and pill count/refill histories.

View Article and Find Full Text PDF

Medication adherence in African-American and European-American pediatric renal transplant recipients was evaluated by four separate measures. Demographic and medical factors were analyzed. Based on pill count/refill history, European-American females were more compliant than their male counterparts.

View Article and Find Full Text PDF

Objectives: To increase knowledge and skills regarding Indigenous learning styles. To raise awareness within the tertiary education sector that Aboriginal students learn differently and that Indigenous cultures and pedagogy have validity and strength. To examine pedagogical strategies that assist both tertiary students capacity for learning and university lecturers' delivery and evaluation of teaching and learning strategies.

View Article and Find Full Text PDF